16469-68-4

Basic information

• Product Name: 1-(4-methoxyphenyl)prop-2-yn-1-one
• Synonyms: 1-(4-Methoxyphenyl)-2-propyn-1-one; 2-propyn-1-one, 1-(4-methoxyphenyl)-
• CAS NO: 16469-68-4
• Molecular Formula: C₁₀H₈O₂
• Molecular Weight: 160.1693
• Mol File: 16469-68-4.mol
• Article Data: 38

Chemical Properties

• Boiling Point: 277.8°C at 760 mmHg
• Flash Point: 120.6°C
• Density: 1.102g/cm³
• Vapor Pressure: 0.00442mmHg at 25°C
• Refractive Index: 1.537
• CAS DataBase Reference: 1-(4-methoxyphenyl)prop-2-yn-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-methoxyphenyl)prop-2-yn-1-one(16469-68-4)
• EPA Substance Registry System: 1-(4-methoxyphenyl)prop-2-yn-1-one(16469-68-4)

Safety Data

• Hazardous Substances Data: 16469-68-4(Hazardous Substances Data)

Upstream product

• 19115-30-1 1-(4-methoxyphenyl)-2-propyn-1-ol 
• 99048-48-3 1‐(4‐methoxyphenyl)‐3‐(trimethylsilyl)prop‐2‐yn‐1‐one 
• 100-07-2 4-methoxy-benzoyl chloride 
• 1066-54-2 trimethylsilylacetylene 
• 123-11-5 4-methoxy-benzaldehyde 
• 74-86-2 acetylene 
• 100-09-4 4-methoxybenzoic acid 
• 52898-49-4 4,N-dimethoxy-N-methylbenzamide 

Downstream Products

• 10493-08-0 4',5,7-trimethoxyflavylium chloride 
• 15724-80-8 3-chloro-1-(4-methoxy-phenyl)-propenone 
• 22882-24-2 3-bromo-1-(4-methoxy-phenyl)-propenone 
• 153142-42-8 2-(p-methoxybenzoylacetaldehyde)-p-nitrophenylhydrazone 
• 130042-85-2 2,3,4,5-tetraphenyl-benzophenone 
• 144712-20-9 1-(4-methoxyphenyl)-2-(1,3-dithian-2-yl)ethan-1-one 
• 17113-31-4 2-(4-methoxyphenyl)furan 
• 62596-42-3 2-Ethyl-5-(4-methoxy-phenyl)-furan 
• 74714-13-9 (4-Methoxy-phenyl)-(6-methyl-4H-chromen-3-yl)-methanone 
• 74714-14-0 (1H-Benzo[f]chromen-2-yl)-(4-methoxy-phenyl)-methanone 
• 130042-86-3 2,5-dimethyl-3,4-diphenyl-benzophenone 
• 18476-67-0 2-(4-methoxyphenyl)-5-methylbenzofuran 
• 153865-95-3 5-(p-methoxybenzoylethynyl)-3',5'-di-O-(p-toluoyl)-2'-deoxyuridine 
• 115492-15-4 2,4-dimethoxy-5-<2-(p-methoxybenzoyl)ethynyl>pyrimidine 

Relevant articles and documents

Mono-Gold(I)-Catalyzed Enantioselective Intermolecular Reaction of Ynones with Styrenes: Tandem Diels–Alder and Ene Sequence

Gold-catalyzed intermolecular reaction leading to dihydronaphthalene derivatives in one pot from two equivalents of ynones with respect to styrene is uncovered. The [4+2] Diels–Alder cycloaddition of ynones and styrenes is catalyzed by a mono-gold(I) complex and the conjugated acid to provide an unstable 3,8a-dihydronaphthalene to subsequently undergo an intermolecular ene-type reaction with the π-activated ynone to afford multi-component coupling dihydronaphthalene products. Linear relationships between chiral ligand-gold complexes and chiral dihydronaphthalene products proves mono-gold catalysis that triggers an asymmetric tandem Diels–Alder and ene reaction sequence.

Metabolically stable vanillin derivatives for the treatment of hypoxia

Vanillin derivative compounds that bind covalently with hemoglobin are provided. Methods of treating sickle cell disease and other hypoxia-related disorders by administering such compounds are also provided.

Copper-catalyzed method for preparing aldehyde or ketone compound by oxidizing alcohol with oxygen as oxidizing agent and application

The invention discloses a copper-catalyzed method for preparing an aldehyde or ketone compound by oxidizing alcohol with oxygen as an oxidizing agent. Reaction is performed in an organic solvent for 4-48 hours at room temperature by using copper salt and nitroxide free radicals as catalysts and oxygen or air as an oxidizing agent to efficiently oxidize an alcohol compound into the corresponding aldehyde or ketone compound. The method is simple to operate, free of chlorides corrosive to equipment, available in raw materials and reagents, mild in reaction conditions, wide in substrate universality, good in functional group compatibility, convenient in separation and purification, environmentally friendly in the whole process and free of pollution, and is a method suitable for industrial production.