16472-97-2

Basic information

• Product Name: Cyclooctanemethanol, 4-methylbenzenesulfonate
• CAS NO: 16472-97-2
• Molecular Formula: C16H24O3S
• Molecular Weight: 296.431
• Mol File: 16472-97-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Cyclooctanemethanol, 4-methylbenzenesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclooctanemethanol, 4-methylbenzenesulfonate(16472-97-2)
• EPA Substance Registry System: Cyclooctanemethanol, 4-methylbenzenesulfonate(16472-97-2)

Safety Data

• Hazardous Substances Data: 16472-97-2(Hazardous Substances Data)

Upstream product

• 1633-64-3 (Z)-2-chlorocyclooct-1-ene-1-carbaldehyde 
• 6688-11-5 cyclooctylcarboxaldehyde 
• 502-49-8 cycloactanone 
• 3637-63-6 cyclooctylmethanol 
• 98-59-9 p-toluenesulfonyl chloride 

Relevant articles and documents

A new approach to the synthesis of the nonpeptide NOP receptor antagonist J-113397

A new synthesis that eliminates the need for chromatographic separation in order to obtain multigram quantities of J-113397, a competitive antagonist of the N/OFQ-NOP receptor system, is reported. N-Benzyl protected 4-oxopiperidinecarboxylate was used as the starting material to obtain an N-benzyl intermediate that could be resolved at a relatively early stage in the synthesis. The crucial step in the synthesis was reduction of the double bond of the β-enaminoester functionality of 1-benzyl-4-(3-ethyl-2-oxo-2,3- dihydrobenzoimidazol-1-yl)-1,2,5,6-tetrahydropyridine-3-carboxylic acid methyl ester, since Pd/C reduction gave inseparable mixtures. It could be reduced and epimerized to the desired trans diastereoisomer in a one-pot reaction by treatment with magnesium metal in methanol. Georg Thieme Verlag Stuttgart.