164803-11-6Relevant articles and documents
Riccardin C derivatives as anti-MRSA agents: Structure-activity relationship of a series of hydroxylated bis(bibenzyl)s
Sawada, Hiromi,Okazaki, Miki,Morita, Daichi,Kuroda, Teruo,Matsuno, Kenji,Hashimoto, Yuichi,Miyachi, Hiroyuki
, p. 7444 - 7447 (2013/02/21)
Members of a series of macrocyclic bis(bibenzyl) riccardin-class derivatives were found to exhibit antibacterial activity towards methicillin-resistant Staphylococcus aureus (anti-MRSA activity). Structure-activity relationship (SAR) studies were conducted, focusing on the number and position of the hydroxyl groups. The minimum essential structure for anti-MRSA activity was also investigated.
[4-(Phenoxy)pyridin-3-yl]methylamines: A new class of selective noradrenaline reuptake inhibitors
Fish, Paul V.,Ryckmans, Thomas,Stobie, Alan,Wakenhut, Florian
, p. 1795 - 1798 (2008/12/21)
[4-(Phenoxy)pyridine-3-yl]methylamines are disclosed as a new series of selective noradrenaline reuptake inhibitors (NRI). Structure-activity relationships established that potent NRI activity could be achieved by appropriate substitution at the 2-position of the phenoxy ring. Compound 31 demonstrated potent NRI activity combined with good selectivity over serotonin and dopamine reuptake and no significant off-target pharmacology.