165112-03-8

Basic information

• Product Name: 2-Methyl-7-hydroxyquinoline
• Synonyms: 2-Methyl-7-hydroxyquinoline;2-Methyl-7-hydroxyquinoine;7-Quinolinol, 2-methyl-;2-methyl-7-Quinolinol;7-Hydroxy-2-methylquinoline;2-Methylquinolin-7-ol
• CAS NO: 165112-03-8
• Molecular Formula: C₁₀H₉NO
• Molecular Weight: 159.18456
• EINECS: -0
• Mol File: 165112-03-8.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 311.7±22.0 °C(Predicted)
• Appearance: /
• Density: 1.210±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 6.48±0.40(Predicted)
• CAS DataBase Reference: 2-Methyl-7-hydroxyquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methyl-7-hydroxyquinoline(165112-03-8)
• EPA Substance Registry System: 2-Methyl-7-hydroxyquinoline(165112-03-8)

Safety Data

• Hazardous Substances Data: 165112-03-8(Hazardous Substances Data)

Usage

General Description

2-Methyl-7-hydroxyquinoline is an organic compound with the chemical formula C10H9NO. It is a derivative of quinoline, with a hydroxyl group and a methyl group attached to the carbon ring. This chemical is used in the synthesis of pharmaceuticals and agrochemicals, as well as in the production of dyes and rubber chemicals. It also has potential antioxidant and antimicrobial properties, making it a potentially useful ingredient in various industrial and consumer products. However, it is important to handle this chemical with caution as it can be harmful if ingested or inhaled, and can cause irritation to the skin and eyes.

Upstream product

• 103853-86-7 7-hydroxy-2-methylquinoline-3-carboxylic acid 
• 19490-87-0 7-methoxy-2-methylquinoline 
• 635-80-3 quinaldine-6-carboxylic acid 
• 7732-18-5 water 
• 7758-99-8 copper(II) sulfate 
• 591-27-5 m-Hydroxyaniline 
• 123-73-9 crotonaldehyde 
• 75896-68-3 4-chloro-7-methoxy-2-methylquinoline 
• 33240-22-1 (E)-3-(3-Methoxy-phenylamino)-but-2-enoic acid ethyl ester 
• 536-90-3 m-Anisidine 
• 4965-33-7 2-methyl-7-chloroquinoline 
• 4965-34-8 2-methyl-7-bromo-quinoline 

Downstream Products

• 475290-87-0 7-tert-butyldiphenylsilyloxy-2-methylquinoline 
• 885684-75-3 8-bromo-2-((2-tosylhydrazono)methyl)quinolin-7-yl acetate 
• 475290-88-1 7-tert-butyldiphenylsilyloxyquinoline-2-carbaldehyde 
• 475290-89-2 (7-tert-butyldiphenylsilyloxy-2-quinolyl)methanol 
• 475290-90-5 (7-((tert-butyldiphenylsilyl)oxy)quinolin-2-yl)methyl acetate 
• 475290-91-6 (7-tert-butyldiphenylsilyloxy-8-bromo-2-quinolyl)methyl acetate 
• 19490-87-0 7-methoxy-2-methylquinoline 
• 1420180-95-5 7-(2,4-dinitrophenoxy)-2-methylquinoline 

Relevant articles and documents

Two-photon fluorescent probes of biological Zn(II) derived from 7-hydroxyquinoline

A new fluorescent probe for monitoring Zn2+ was synthesized based on the structure of 7-hydroxyquinoline. Compared with 8-substituted quinolines, the new probe exhibited higher selectivity for Zn2+ over Cd2+. Its fluoresce

Synthesis and in vitro evaluation of charge reversal photoresponsive quinoline tethered mesoporous silica for targeted drug delivery

We developed excellent charge reversal photoresponsive nanoparticles for targeted delivery of the anticancer drug chlorambucil. The charge reversal photoresponsive nanoparticles were constructed using two main ingredients, namely folic acid decorated mesoporous silica and quinoline chromophore. The newly synthesized quinoline chromophore performed three important roles, i.e., (i) fluorescent chromophore for cell imaging, (ii) phototrigger for regulated release of anticancer drug, and (iii) charge reversal based on its zeta potential for nuclear localization. Furthermore, folic acid decorated mesoporous silica facilitated active internalization of the drug inside the cancer cells. In vitro biological studies reveal that our photoresponsive DDS could deliver the anticancer drug chlorambucil into the tumor cells, killing the cancer cells by both one photon (≥365 nm) and two photon (675 nm) irradiation. This journal is

Copper-Catalyzed Hydroxylation of (Hetero)aryl Halides under Mild Conditions

The combination of Cu(acac)2 and N,N′-bis(4-hydroxyl-2,6-dimethylphenyl)oxalamide (BHMPO) provides a powerful catalytic system for hydroxylation of (hetero)aryl halides. A wide range of (hetero)aryl chlorides bearing either electron-donating or -withdrawing groups proceeded well at 130 °C, delivering the corresponding phenols and hydroxylated heteroarenes in good to excellent yields. When more reactive (hetero)aryl bromides and iodides were employed, the hydroxylation reactions completed at relatively low temperatures (80 and 60 °C, respectively) at low catalytic loadings (0.5 mol % Cu).