16537-06-7

Basic information

• Product Name: Cyclohexaneacetic acid, 1,1-dimethylethyl ester
• Synonyms: tert-Butyl cyclohexylacetate;Cyclohexylessigsaeure-tert.-butylester;Cyclohexyl-acetic acid tert-butyl ester
• CAS NO: 16537-06-7
• Molecular Formula: C12H22O2
• Molecular Weight: 198.305
• Mol File: 16537-06-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Cyclohexaneacetic acid, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexaneacetic acid, 1,1-dimethylethyl ester(16537-06-7)
• EPA Substance Registry System: Cyclohexaneacetic acid, 1,1-dimethylethyl ester(16537-06-7)

Safety Data

• Hazardous Substances Data: 16537-06-7(Hazardous Substances Data)

Upstream product

• 5469-33-0 cyclohexylmethyl iodide 
• 201230-82-2 carbon monoxide 
• 865-48-5 sodium t-butanolate 
• 86302-43-4 (tert-Butoxycarbonylmethylene)triphenylphosphorane 
• 108-93-0 cyclohexanol 
• 88931-74-2 (E)-8-Iodo-oct-2-enoic acid tert-butyl ester 
• 110-82-7 cyclohexane 
• 35059-50-8 t-butyl diazoacetate 

Relevant articles and documents

Copper-Catalyzed Alkoxycarbonylation of Alkyl Iodides for the Synthesis of Aliphatic Esters: Hydrogen Makes the Difference

A copper-catalyzed alkoxycarbonylation transformation of unactivated alkyl iodides has been developed. Various alkyl iodides can be converted into the corresponding tert-butyl esters in good yields. NaOtBu acts as both a nucleophile and a base. Moreover, other types of aliphatic esters can also be obtained in moderated yields if extra alcohols are added. Both primary and secondary alkyl alcohols can react successfully.

Metal-Halogen Exchange-Initiated Intramolecular Conjugate Addition Reactions of Unsaturated Esters

Intramolecular conjugate addition reactions of internal unstabilized nucleophilic centers formed through rapid lithium-halogen exchange reactions have been used to generate carbocycles from ω-iodo-α,β-unsaturated esters.