165736-03-8

Basic information

• Product Name: (2-PHENYL-1,3-THIAZOL-4-YL)METHYLAMINE
• Synonyms: (2-PHENYL-1,3-THIAZOL-4-YL)METHYLAMINE;(2-PHENYL-1,3-THIAZOL-4-YL)METHANAMINE;AKOS B006895;CHEMBRDG-BB 4101065;C-(2-PHENYL-THIAZOL-4-YL)-METHYLAMINE;2-phenyl 4- thiazolemethanamine;4-(Aminomethyl)-2-phenyl-1,3-thiazole;1-(2-phenyl-1,3-thiazol-4-yl)methanamine(SALTDATA: 2HCl)
• CAS NO: 165736-03-8
• Molecular Formula: C₁₀H₁₀N₂S
• Molecular Weight: 190.26
• Product Categories: Heterocycle
• Mol File: 165736-03-8.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 118-22°C 0,01mm
• Flash Point: 167.4°C
• Appearance: /
• Density: 1.208g/cm³
• Vapor Pressure: 3.65E-05mmHg at 25°C
• Refractive Index: 1.626
• CAS DataBase Reference: (2-PHENYL-1,3-THIAZOL-4-YL)METHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: (2-PHENYL-1,3-THIAZOL-4-YL)METHYLAMINE(165736-03-8)
• EPA Substance Registry System: (2-PHENYL-1,3-THIAZOL-4-YL)METHYLAMINE(165736-03-8)

Safety Data

• Hazard Codes: C,Xi
• Statements: 36/37/38-34
• Safety Statements: 26-36/37/39-45
• RIDADR: 2735
• HazardClass: IRRITANT
• Hazardous Substances Data: 165736-03-8(Hazardous Substances Data)

Usage

General Description

(2-Phenyl-1,3-thiazol-4-yl)methylamine is a chemical compound with the molecular formula C9H7N3S. It is an organic compound that contains a thiazole ring, a phenyl group, and an amine functional group. (2-Phenyl-1,3-thiazol-4-yl)methylamine is commonly used in pharmaceutical research and drug development due to its potential biological activity. It has been studied for its potential as an antimicrobial and antioxidant agent, as well as for its potential anti-cancer properties. Additionally, it has been used as a building block in the synthesis of various pharmaceutical compounds. The chemical structure and properties of (2-Phenyl-1,3-thiazol-4-yl)methylamine make it a valuable tool in medicinal chemistry and drug discovery.

InChI:InChI=1/C10H10N2S/c11-6-9-7-13-10(12-9)8-4-2-1-3-5-8/h1-5,7H,6,11H2

Upstream product

• 4771-31-7 2-phenyl-4-chloromethylthiazole 
• 2227-79-4 benzenecarbothioamide 
• 65-85-0 benzoic acid 
• 59937-01-8 2-phenylthiazole-4-carboxylic acid ethyl ester 
• 23780-13-4 (2-phenylthiazol-4-yl)methanol 
• 98-88-4 benzoyl chloride 

Downstream Products

• 486435-48-7 N-(2-phenylthiazol-4-ylmethyl)-4-(4'-trifluoromethylbiphenyl-2-carbonylamino)-1-methyl-pyrrole-2-carboxylic acid amide 
• 1394122-29-2 C₃₀H₃₈N₈O₂S₂ 
• 1394122-30-5 C₃₁H₄₀N₈O₂S₂ 
• 1394122-31-6 C₃₁H₄₀N₈O₂S₂ 
• 1394122-32-7 C₃₂H₄₀N₈O₂S₂ 
• 1394122-33-8 C₃₀H₃₆N₈O₂S₂ 
• 1394122-34-9 C₃₂H₄₀N₈O₂S₂ 
• 1394122-35-0 C₃₀H₃₅N₉O₂S₂ 
• 1394122-36-1 C₂₉H₃₆N₈O₃S₂ 
• 1394122-37-2 C₃₀H₃₈N₈O₃S₂ 
• 1394122-38-3 C₃₃H₄₂N₈O₃S₂ 
• 1394122-39-4 C₂₉H₃₁F₃N₈O₂S₂ 
• 1394122-54-3 C₂₉H₃₁F₃N₈O₂S₂ 
• 1394122-55-4 N-{[(3S)-1-(4-(3-buten-1-ylamino)-6-{[(2-phenyl-1,3-thiazol-4-yl)methyl]amino}-1,3,5-triazin-2-yl)-3-pyrrolidinyl]methyl}-4-(trifluoromethyl)benzenesulfonamide 

Relevant articles and documents

Regioselectivity evaluation of the (Z)-5-(4-hydroxybenzylidene)-thiazolidine-2,4?dione alkylation in alkaline environment

Thiazolidine-2,4?dione represents a key heterocyclic core in medicinal chemistry because it has the ability to bind to a wide variety of protein targets and has been intensively studied for developing bioactive multitargeting agents. The N-alkylation of i

Design, synthesis and evaluation of phenylthiazole and phenylthiophene pyrimidindiamine derivatives targeting the bacterial membrane

As the continuous rise in the incidence of antibiotic resistance, it is urgent to develop novel chemical scaffolds with antibacterial activities to control the spread of resistance to conventional antibiotics. In this study, a series of phenylthiazole and

Design, synthesis, DFT study and antifungal activity of the derivatives of pyrazolecarboxamide containing thiazole or oxazole ring

Pyrazolecarboxamide fungicides are one of the most important classes of agricultural fungicides, which belong to succinodehydrogenase inhibitors (SDHIS). To discover new pyrazolecarboxamide analogues with broad spectrum and high activity, a class of new compounds of pyrazole carboxamide derivatives containing thiazole or oxazole ring were designed by scaffold hopping and bioisosterism, and 36 pyrazole carboxamide derivatives with antifungal activity were synthesized. Those compounds were evaluated against five phytopathogenic fungi, Gibberella zeae, Phytophythora capsici, Sclerotonia sclerotiorum, Erysiphe graminis and Puccinia sorghi. The results indicated that most of the compounds displayed good fungicidal activities, especially against E. graminis. Theoretical calculations were carried out at the B3LYP/6-31G (d, p) level and the full geometry optimization was carried out using the 6-31G (d, p) basis set, and the frontier orbital energy, atomic net charges, molecular docking were discussed, and the structure-activity relationships were also studied.