16576-78-6

Basic information

• Product Name: 2-(1H-IMIDAZOL-4-YL)-PYRIDINE
• Synonyms: 2-(1H-IMIDAZOL-4-YL)-PYRIDINE;2-(1H-Imidazol-5-yl)pyridine
• CAS NO: 16576-78-6
• Molecular Formula: C₈H₇N₃
• Molecular Weight: 145.16128
• Mol File: 16576-78-6.mol
• Article Data: 9

Chemical Properties

• Melting Point: 40-41 °C
• Boiling Point: 406.8±20.0 °C(Predicted)
• Appearance: /
• Density: 1.214±0.06 g/cm3(Predicted)
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 12.55±0.10(Predicted)
• CAS DataBase Reference: 2-(1H-IMIDAZOL-4-YL)-PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1H-IMIDAZOL-4-YL)-PYRIDINE(16576-78-6)
• EPA Substance Registry System: 2-(1H-IMIDAZOL-4-YL)-PYRIDINE(16576-78-6)

Safety Data

• Hazardous Substances Data: 16576-78-6(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron Letters, 29, p. 5013, 1988 DOI: 10.1016/S0040-4039(00)80667-X

Upstream product

• 858513-34-5 4-[2]pyridyl-1,3-dihydro-imidazole-2-thione 
• 239798-77-7 2-[4-(toluene-4-sulfonyl)-4,5-dihydro-oxazol-5-yl]-pyridine 
• 1121-60-4 pyridine-2-carbaldehyde 
• 51746-81-7 2-amino-1-[2]pyridyl-ethanone; monohydrochloride 
• 38622-91-2 [(p-methylphenyl)sulfonylmethyl]isonitrile 
• 120671-11-6 1-ethoxymethyl-2-phenylthio-5-(2-pyridinyl)imidazole 
• 109-04-6 2-bromo-pyridine 
• 17570-98-8 2-(bromoacetyl)pyridine hydrobromide 
• 77287-34-4 formamide 

Downstream Products

• 501660-37-3 [1-(4-chloro-benzyl)-1H-indol-3-yl]-[4-pyridin-2-yl-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-methanol 
• 501660-38-4 [1-(4-chloro-benzyl)-1H-indol-3-yl]-[4-pyridin-2-yl-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-methanone 

Relevant articles and documents

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THERAPEUTIC COMPOUNDS AND USES THEREOF

The present invention relates to compounds formula (I): and to salts thereof, wherein R1-R4 and A have any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of histone demethylases, such as KDM5. Also included are pharmaceutically acceptable compositions comprising the compounds of the present invention and methods of using said compositions in the treatment of various disorders.

INHIBITORS OF AKT ACTIVITY

The present invention is directed to compounds which contain substituted naphthyridines which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention. These substituted naphthyridines have unexpected advantageous properties when compared to other naphthyridines reported in PCT publication WO2003/086394, such unexpected advantageous properties may include increased cellular potency/solubility, greater selectivity, enhanced pharmacokinetic properties, lack of off target activity and so on.