16671-86-6Relevant articles and documents
DNA Alkylation by leinamycin can be triggered by cyanide and phosphines
Zang, Hong,Breydo, Leonid,Mitra, Kaushik,Dannaldson, Jeffrey,Gates, Kent S.
, p. 1511 - 1515 (2001)
Previous work has shown that alkylation of DNA by the antitumor agent leinamycin (1) is potentiated by reaction of the antibiotic with thiols. Here, it is shown that other soft nucleophiles such as cyanide and phosphines can also trigger DNA alkylation by leinamycin. Overall, the results suggest that reactions of cyanide and phosphines with leinamycin produce the oxathiolanone intermediate (2), which is known to undergo rearrangement to the DNA-alkylating episulfonium ion 4.