166959-67-7

Basic information

• Product Name: 4-(2-cyanoethyl)phenyl(trifluoromethyl)sulfonate
• Synonyms: 4-(2-cyanoethyl)phenyl(trifluoromethyl)sulfonate
• CAS NO: 166959-67-7
• Molecular Weight: 279.24
• Mol File: 166959-67-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-(2-cyanoethyl)phenyl(trifluoromethyl)sulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-cyanoethyl)phenyl(trifluoromethyl)sulfonate(166959-67-7)
• EPA Substance Registry System: 4-(2-cyanoethyl)phenyl(trifluoromethyl)sulfonate(166959-67-7)

Safety Data

• Hazardous Substances Data: 166959-67-7(Hazardous Substances Data)

Upstream product

• 17362-17-3 3-(p-hydroxyphenyl)propiononitrile 
• 358-23-6 trifluoromethylsulfonic anhydride 
• 456-64-4 phenyl trifluoromethanesulfonamide 
• 14482-11-2 p-methoxycinnamonitrile 
• 22442-48-4 3-(4-methoxyphenyl)propionitrile 
• 696-62-8 para-iodoanisole 

Downstream Products

• 1220219-19-1 3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]propanenitrile 

Relevant articles and documents

Terphenyl-based helical mimetics that disrupt the p53/HDM2 interaction

(Chemical Equation Presented) HDM2 regulates p53 by binding to its transactivation domain and promoting its ubiquitin-dependent degradation. Crystallographic analysis of the HDM2/p53 complex revealed that three hydrophobic residues (F19, W23, L26) along one face of the p53 helical peptide are essential for binding (see picture). Terphenyl-based antagonists mimic the α-helical region of p53 and disrupt HDM2/p53 complexation.