167105-80-8 Usage
Description
Ketorolac Related Compound A (20 mg) (5-benzoyl-N-(1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl)-2,3-dihydro-1H-pyrrolizine-1-carboxamide) is a chemical compound derived from Ketorolac, a nonsteroidal anti-inflammatory drug (NSAID) used for short-term pain management. It is characterized by its unique chemical structure, which includes a benzoyl group and a pyrrolizine ring, and is identified as an impurity in the pharmaceutical formulation of Ketorolac.
Uses
Used in Pharmaceutical Industry:
Ketorolac Related Compound A (20 mg) (5-benzoyl-N-(1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl)-2,3-dihydro-1H-pyrrolizine-1-carboxamide) is used as an impurity reference substance for the quality control and analysis of Ketorolac (K235650) in the pharmaceutical industry. Its presence in the drug formulation needs to be monitored and controlled to ensure the safety, efficacy, and purity of the final product.
Used in Research and Development:
In the field of drug development and medicinal chemistry, Ketorolac Related Compound A serves as a valuable research tool for understanding the structure-activity relationship of Ketorolac and its analogs. It can be used to investigate the effects of structural modifications on the pharmacological properties, such as anti-inflammatory, analgesic, and side effects, of the drug.
Used in Quality Control and Regulatory Compliance:
Ketorolac Related Compound A is utilized in the development and validation of analytical methods for the quantification of impurities in Ketorolac drug products. This helps in ensuring that the drug meets the required quality standards and regulatory guidelines, such as those set by the United States Pharmacopeia (USP) and the European Pharmacopeia (EP).
Check Digit Verification of cas no
The CAS Registry Mumber 167105-80-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,7,1,0 and 5 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 167105-80:
(8*1)+(7*6)+(6*7)+(5*1)+(4*0)+(3*5)+(2*8)+(1*0)=128
128 % 10 = 8
So 167105-80-8 is a valid CAS Registry Number.
167105-80-8Relevant articles and documents
Approaches for improving the stability of ketorolac in powder blends
Brandl,Magill,Rudraraju,Gordon
, p. 1151 - 1153 (1995)
Methods for improving the stability of ketorolac powder blends under elevated humidity and temperature conditions were investigated. The approaches that were examined for potentially increasing the stability of ketorolac were varying the ketorolac salt form, altering the excipient ratios, and adding antioxidants or pH modifiers to the formulation. The ketorolac powder blends were stored for 3 months at 75% relative humidity (RH) and 40, 50, and 60 °C. The results showed that the salt form of ketorolac had a large impact on stability after 3 months of storage at 50 °C/75% RH. The calcium salt powder blend and the free acid powder blend exhibited only 0.2% and 0.5% drug loss, respectively, whereas the tromethamine salt powder blend showed a 10.2% drug loss. Varying the ratios of lactose, microcrystalline cellulose, and croscarmellose sodium in the powder blends of ketorolac tromethamine showed that croscarmellose sodium and microcrystalline cellulose destabilized ketorolac. Addition of propyl gallate (1% w:w) to ketorolac tromethamine powder blends increased the stability of the ketorolac significantly. Addition of pH modifiers caused a modest improvement in the stability of ketorolac.
