16732-64-2

Basic information

• Product Name: 4-Bromo-2-indolecarboxylic acid
• Synonyms: 4-BROMO-2-INDOLECARBOXYLIC ACID;4-BROMO-1H-INDOLE-2-CARBOXYLIC ACID;1H-Indole-2-carboxylicacid, 4-bromo-;Indole-2-carboxylic acid, 4-bromo-
• CAS NO: 16732-64-2
• Molecular Formula: C₉H₆BrNO₂
• Molecular Weight: 240.05
• Product Categories: Indole
• Mol File: 16732-64-2.mol
• Article Data: 5

Chemical Properties

• Melting Point: 263 °C
• Boiling Point: 470.9 °C at 760 mmHg
• Flash Point: 238.6 °C
• Appearance: /
• Density: 1.838 g/cm³
• Vapor Pressure: 1.13E-09mmHg at 25°C
• Refractive Index: 1.749
• Storage Temp.: 2-8°C
• PKA: 4.23±0.30(Predicted)
• CAS DataBase Reference: 4-Bromo-2-indolecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Bromo-2-indolecarboxylic acid(16732-64-2)
• EPA Substance Registry System: 4-Bromo-2-indolecarboxylic acid(16732-64-2)

Safety Data

• RIDADR: UN2811
• Hazardous Substances Data: 16732-64-2(Hazardous Substances Data)

Usage

General Description

4-Bromo-2-indolecarboxylic acid is a chemical substance with the molecular formula C9H6BrNO2. It is used primarily in scientific research, particularly in organic chemistry. It is a compound that functions as a precursor or intermediary in chemical reactions, particularly those involving the formation of larger, more complex organic molecules. It is identified by its CAS number 4805-74-3. Given its specific structure and properties, this compound must be handled with caution, typically under controlled laboratory conditions, by trained professionals. Its physical appearance is generally described as a white to off-white powder.

InChI:InChI=1/C9H6BrNO2/c10-6-2-1-3-7-5(6)4-8(11-7)9(12)13/h1-4,11H,(H,12,13)

Upstream product

• 98592-11-1 6-bromo-2-nitrophenylpyruvic acid 
• 103858-52-2 4-bromo-1H-Indole-2-carboxylic acid ethyl ester 
• 55289-35-5 2-bromo-6-nitrotoluene 
• 608510-29-8 ethyl 3-(2-bromo-6-nitrophenyl)-2-oxopropanoate 
• 52488-36-5 4-bromo-1H-indole 
• 79-37-8 oxalyl dichloride 

Downstream Products

• 52488-36-5 4-bromo-1H-indole 
• 103858-52-2 4-bromo-1H-Indole-2-carboxylic acid ethyl ester 
• 861213-76-5 4-(2-ethylphenyl)-1H-indole-2-carboxylic acid 
• 863251-48-3 4-(4-methoxy-phenyl)-1H-indole-2-carboxylic acid 
• 1026201-88-6 4-bromo-1-phenyl-1H-indole-2-carboxylic acid 
• 1146213-77-5 (4-bromo-1H-indol-2-yl)(4-(4-fluorobenzyl)piperazin-1-yl)methanone 
• 1182349-19-4 4-(2-propylphenyl)-1H-indole-2-carboxylic acid 
• 1182349-15-0 2-benzyloxycarbonylamino-3-[(4-bromo-1H-indole-2-carbonyl)amino]propionic acid methyl ester 
• 1182349-18-3 4-o-tolyl-1H-indole-2-carboxylic acid 
• 1182349-25-2 4-(2-methoxyphenyl)-1H-indole-2-carboxylic acid 
• 1210365-31-3 4-(2-isopropylphenyl)-1H-indole-2-carboxylic acid 
• 1210043-05-2 C₂₁H₂₀BrN₃O₅ 
• 1411992-72-7 C₃₂H₄₂BN₃O₅ 
• 1411994-03-0 C₂₇H₃₄BN₃O₃ 

Relevant articles and documents

4 - bromo - 2 - hydroxy indole synthesis method (by machine translation)

The present invention provides 4 - bromo - 2 - hydroxy indole synthesis method, its steps are as follows: (1) the aluminum powder and zirconium oxide grinding ball into the ball mill pot ball grinding pre-processing aluminum powder; (2) hydrogenation the sodium uses pentane is pretreated pre-processing sodium hydride; (3) the pre-processing of aluminum powder and pretreatment sodium hydride, zirconium oxide grinding ball, to join the ball rubs the pot ball grindingnitric acid titanium, products of sodium aluminum hydride; (4) there will be aluminum nitrate, nitrate by the sol - gel process compound indium catalyst; (5) the α - (N, N - dimethylamino) - 2 - bromo - 6 nitrobenzene ethylene for the cyclization catalyst reduction compound indium prepared 4 - bromo indole; (6) the 4 - bromo indole with oxalyl, methanol prepared through the reaction of 4 - bromo indole - 2 - carboxylic acid; (7) will be 4 - bromo indole - 2 - carboxylic acid is sodium aluminum hydride reduction to obtain the target product. The invention of high yield, low cost. (by machine translation)

The first potent and selective non-imidazole human histamine H4 receptor antagonists

Following the discovery of the human histamine H4 receptor, a high throughput screen of our corporate compound collection identified compound 6 as a potential lead. Investigation of the SAR resulted in the discovery of novel compounds 10e and 10l, which are the first potent and selective histamine H4 receptor antagonists to be described.

Indoline Analogues of Idazoxan: Potent α2-Antagonists and α1-Agonists

The synthesis and α-adrenergic activity of a series of substituted 2-imidazolinylindolines are described.Substitution in the indoline ring generated compounds with a spectrum of adrenoceptor antagonist/agonist profiles that proved sensitive to both the nature and position of the substituent.Many of the derivatives possess greater presynaptic antagonist potency that the corresponding benzodioxan 1, dihydrobenzofuran 2, and indan 3 analogues; however, this α2-antagonism is often accompanied by α1-agonist activity.It was not possible to separate α2-antagonist from α1-agonist properties in this series.Compounds of most interest proved to be the N-ethyl 6, 5-chloro-N-methyl 18 and 5-chloro-N-ethyl 23 derivatives, all being potent α2-antagonists and α1-agonists.Substitution at the 4- and 7-position of the indoline ring generally gave compounds with nonselective agonist properties.