167354-91-8 Usage
Description
(+/-)-13-HYDROXY-9Z,11E-OCTADECADIENOIC ACID, CHOLESTERYL ESTER, also known as (±)13-HODE cholesteryl ester, is a complex lipid molecule derived from the oxidation of low-density lipoprotein (LDL). It was originally extracted from atherosclerotic lesions and has been identified as a product of the metabolism of cholesteryl linoleate, a major component of LDL, by 15-lipoxygenase (15-LO) from rabbit reticulocytes and human monocytes.
Uses
Used in Atherosclerosis Research:
(+/-)-13-HYDROXY-9Z,11E-OCTADECADIOENOIC ACID, CHOLESTERYL ESTER is used as a biomarker for atherosclerosis in the field of medical and cardiovascular research. Its presence in atherosclerotic lesions indicates its involvement in the development and progression of the disease.
Used in Cellular Metabolism Studies:
In the field of cellular and molecular biology, (+/-)-13-HYDROXY-9Z,11E-OCTADECADIOENOIC ACID, CHOLESTERYL ESTER serves as a substrate for studying the metabolism of cholesteryl linoleate by 15-LO enzymes in rabbit reticulocytes and human monocytes. This helps researchers understand the biochemical pathways and mechanisms involved in the formation of this molecule.
Used in Drug Development:
(+/-)-13-HYDROXY-9Z,11E-OCTADECADIOENOIC ACID, CHOLESTERYL ESTER may be used as a target for drug development in the pharmaceutical industry. By understanding its role in atherosclerosis and its metabolic pathways, researchers can potentially develop therapeutic agents to modulate its production or effects, thereby treating or preventing atherosclerosis and related cardiovascular diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 167354-91-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,7,3,5 and 4 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 167354-91:
(8*1)+(7*6)+(6*7)+(5*3)+(4*5)+(3*4)+(2*9)+(1*1)=158
158 % 10 = 8
So 167354-91-8 is a valid CAS Registry Number.
167354-91-8Relevant articles and documents
Preparation of fatty acid cholesterol ester hydroperoxides by photosensitized oxidation
El Hafidi,Michel,Bascoul,Crastes De Paulet
, p. 127 - 138 (2007/10/03)
Preparation of fatty acid cholesterol ester hydroperoxides was undertaken with the purpose of evaluating their biological effects on cell growth. Cholesterol stearate, oleate, linoleate and α-linolenate were oxidized using methylene blue as a photosensitizer. The structures of all compounds were established by mass spectrometry and by nuclear magnetic resonance. The photosensitized oxidation of cholesterol oleate gave two hydroperoxide isomers: 9-hydroperoxy-trans-10-octadecenoate, and 10-hydroperoxy-trans-8-octadecenoate. In the case of the cholesterol linoleate, hydroperoxide isomers formed were: 9-hydroperoxy-trans-10, cis-12-octadecadienoate; 10-hydroperoxy-trans-8, cis-12-octadecadienoate; 12-hydroperoxy-cis-9, trans-13-octadecadienoate; 13-hydroperoxy-cis-9, trans-11-octadecadienoate. The oxidation of the cholesterol α-linolenate gave a mixture of six hydroperoxide isomers, at positions 9, 10, 12, 13, 15 and 16 of the fatty acid chain. The photosensitized oxidation of cholesterol stearate produced a formation of hydroperoxide at position 5α of cholesterol. The same hydroperoxide isomers on the fatty acid chain were obtained as described in the literature for the fatty acid methyl esters. Copyright (C) 1999 Elsevier Science Ireland Ltd.
