167780-11-2

Basic information

• Product Name: 1-Propanone, 3-(2-chlorophenyl)-3-hydroxy-1-phenyl-
• CAS NO: 167780-11-2
• Molecular Formula: C15H13ClO2
• Molecular Weight: 260.72
• Mol File: 167780-11-2.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 1-Propanone, 3-(2-chlorophenyl)-3-hydroxy-1-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Propanone, 3-(2-chlorophenyl)-3-hydroxy-1-phenyl-(167780-11-2)
• EPA Substance Registry System: 1-Propanone, 3-(2-chlorophenyl)-3-hydroxy-1-phenyl-(167780-11-2)

Safety Data

• Hazardous Substances Data: 167780-11-2(Hazardous Substances Data)

Usage

Physical state

White solid at room temperature

Common uses

Synthesis of pharmaceuticals, organic compounds, solvent, intermediate in chemical production

Industrial applications

Pharmaceutical and chemical industries

Ongoing research

Properties and potential uses

Upstream product

• 65480-18-4 (3-(2-chlorophenyl)oxiran-2-yl)(phenyl)methanone 
• 14762-47-1 2-diazo-3-oxo-3-phenylpropanal 
• 89-98-5 2-chloro-benzaldehyde 
• 15397-33-8 3-Oxo-3-phenylpropanal 
• 98-86-2 acetophenone 
• 3300-67-2 3-(2-chlorophenyl)-1-phenylpropenone 
• 70-11-1 α-bromoacetophenone 

Downstream Products

• 89-98-5 2-chloro-benzaldehyde 
• 98-86-2 acetophenone 

Relevant articles and documents

-

-

PAA-supported Hantzsch 1,4-dihydropyridine ester: An efficient catalyst for the hydrogenation of α,β-epoxy ketones

A new type of water-soluble polymer-supported NADH co-enzyme model-PAA (polyacrylic acid)-supported Hantzsch 1,4-dihydropyridine ester (PAA-HEH) was designed and synthesized. Catalytic amount of the supported reagent was used in the hydrogenation of α,β-epoxy ketones to the corresponding β-hydroxy ketones and showed great catalytic efficiency in the reduction reaction. This PAA-HEH was an optimal potential for recycling use.

Chemoselectivity in the reaction of 2-diazo-3-oxo-3-phenylpropanal with aldehydes and ketones

The chemoselectivity in the reaction of 2-diazo-3-oxo-3-phenylpropanal (1) with aldehydes and ketones in the presence of Et3N was investigated. The results indicate that 1 reacts with aromatic aldehydes with weak electron-donating substituents and cyclic ketones under formation of 6-phenyl-4H-1,3-dioxin-4-one derivatives. However, it reacts with aromatic aldehydes with electron-withdrawing substituents to yield 1,3-diaryl-3-hydroxypropan-1-ones, accompanied by chalcone derivatives in some cases. It did not react with linear ketones, aliphatic aldehydes, and aromatic aldehydes with strong electron-donating substituents. A mechanism for the formation of 1,3-diaryl-3-hydroxypropan-1-ones and chalcone derivatives is proposed. We also tried to react 1 with other unsaturated compounds, including various olefins and nitriles, and cumulated unsaturated compounds, such as N,N′-dialkylcarbodiimines, phenyl isocyanate, isothiocyanate, and CS2. Only with N,N′-dialkylcarbodiimines, the expected cycloaddition took place. Copyright