167889-09-0

Basic information

• Product Name: 2-<2-(1-azabicyclo<3.3.0>octan-5-yl)ethylamino>benzonitrile
• Synonyms: 2-<2-(1-azabicyclo<3.3.0>octan-5-yl)ethylamino>benzonitrile
• CAS NO: 167889-09-0
• Molecular Weight: 255.363
• Mol File: 167889-09-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-<2-(1-azabicyclo<3.3.0>octan-5-yl)ethylamino>benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-<2-(1-azabicyclo<3.3.0>octan-5-yl)ethylamino>benzonitrile(167889-09-0)
• EPA Substance Registry System: 2-<2-(1-azabicyclo<3.3.0>octan-5-yl)ethylamino>benzonitrile(167889-09-0)

Safety Data

• Hazardous Substances Data: 167889-09-0(Hazardous Substances Data)

Upstream product

• 394-47-8 2-fluorobenzonitrile 
• 78449-78-2 7a-(2-aminoethyl)hexahydro-1H-pyrrolizine 

Relevant articles and documents

Synthesis and muscarinic activity of novel aniline derivatives with a 1- azabicyclo[3.3.0]octane moiety

In order to develop drugs effective against Alzheimer's disease, we synthesized a series of aniline derivatives having a characteristic cyclic amine, 1-azabicyclo[3.3.0]octane ring, and evaluated their binding affinity for the central muscarinic cholinergic receptor. Among these compounds which showed high affinity to the M1 receptor, N-[2-(1-Azabicyclo[3.3.0]octan-5- yl)ethyl]-2-nitroaniline (9f fumarate, SK-946) showed the highest affinity. The ability of this compound to improve cognitive function was assessed using the passive avoidance test in scopolamine-induced dementia mice. Some anilines with a 1-azabicyclo[3.3.1]nonane ring were also synthesized by the ring expansion of the 1-azabicyclo[3.3.0]octane ring, and showed a high affinity for the central muscarinic cholinergic receptor.