16799-05-6

Basic information

• Product Name: 3-CHLOROPHENETHYL BROMIDE, 97%
• Synonyms: 1-Bromo-2-(3-chlorophenyl)ethane;1-(2-Bromo-ethyl)-3-chloro-benzene;3-Chloro-1-(2-bromoethyl)benzene;3-Chlorophenethyl bromide
• CAS NO: 16799-05-6
• Molecular Formula: C₈H₈BrCl
• Molecular Weight: 219.51
• Mol File: 16799-05-6.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 239.3 °C at 760 mmHg
• Flash Point: 110 °C
• Appearance: /
• Density: 1.489 g/cm³
• Vapor Pressure: 0.0623mmHg at 25°C
• Refractive Index: 1.571
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 3-CHLOROPHENETHYL BROMIDE, 97%(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLOROPHENETHYL BROMIDE, 97%(16799-05-6)
• EPA Substance Registry System: 3-CHLOROPHENETHYL BROMIDE, 97%(16799-05-6)

Safety Data

• Hazard Codes: Xn,N
• Statements: 22-41-51/53
• Safety Statements: 26-36/37-39-61
• RIDADR: UN 3082 9/PG 3
• WGK Germany: 2
• Hazardous Substances Data: 16799-05-6(Hazardous Substances Data)

Usage

General Description

3-Chlorophenethyl bromide, 97%, is a clear, colorless liquid chemical used primarily in organic synthesis. This specialty chemical is a halide, featuring both a bromide (Br) and a chloride (Cl) within its molecular structure. Its molecular formula is C8H8BrCl. This chemical compound exhibits a relatively high purity level of 97%, indicating the minimal presence of impurities. Its high reactivity and efficacy make it useful in conducting various laboratory experiments and producing other complex organic compounds across multiple industries. Like other halides, it needs to be handled with care due to its potential hazard characteristics.

InChI:InChI=1/C8H8BrCl/c9-5-4-7-2-1-3-8(10)6-7/h1-3,6H,4-5H2

Upstream product

• 5182-44-5 2-(3-chlorophenyl)ethanol 
• 1878-65-5 3-chlorophenylacetic acid 
• 108-37-2 1-bromo-3-chlorobenzene 
• 2039-85-2 3-Chlorostyrene 

Downstream Products

• 89978-80-3 1-chloro-3-(2-iodoethyl)benzene 
• 21640-47-1 3‐(3‐chlorophenyl)propanenitrile 
• 25017-13-4 1-(2-bromoethyl)-3-fluorobenzene 
• 18655-49-7 3-(3-Chloro-phenyl)-propylamine 
• 18001-49-5 2-<3-Chlorphenyl>-aethyl-trimethylsilan 
• 18411-98-8 Trimethyl-<3-(2-trimethylsilyl-aethyl)-phenyl>-silan 
• 177550-34-4 tert-Butyl {9-[2-(3-Chlorophenyl)ethyl]-4-methyl-1-methylthio-carbazol-2-yl}acetate 
• 129254-96-2 1-(3-chlorophenyl)-3-(3-ethyl-pyridin-4-yl)-propane 
• 129254-84-8 1-(3-chlorophenyl)-3-(pyridin-4-yl)-butane 
• 113240-38-3 1-[2-(3-chlorophenyl)-ethyl]piperazine 
• 849943-48-2 5-{[2-(3-chlorophenyl)ethyl]thio}-7-{[(1R)-1-(hydroxymethyl)-3-methylbutyl]amino}[1,3]thiazolo[4,5-d]pyrimidin-2(3H)-one 
• 1246656-49-4 S-(3-chlorophenethyl)isothiourea hydrobromide 
• 1034916-85-2 Br^(1-)*C₂₇H₃₆ClN₂O₂S⁽¹⁺⁾ 
• 1382354-29-1 2-{3-(3-chlorophenethoxy)phenylamino}benzamide 

Relevant articles and documents

Preparation method for hemihydrate lorcaserin hydrochloride

The invention discloses a preparation method for hemihydrate lorcaserin hydrochloride. The preparation method comprises the following steps: (1) making a compound shown as a formula III react with ammonia to obtain a compound shown as a formula II; (2) under the protection of nitrogen gas, dissolving the compound shown as the formula II in an organic solvent, adding a hydrogen chloride solution of which the solvent is the organic solvent to salify, and adding water and cyclohexane to form a hemihydrate in order to obtain the compound shown as a formula I, wherein the organic solvent is isopropanol or 1,4-dioxane. In the preparation method disclosed by the invention, ammonium hydroxide substitutes for potassium carbonate in the prior art, so that unqualified ignition residues of a finial product caused by potassium chloride generated after salt removal can be avoided; an isopropoxide hydrochloride solution substitutes for the conventional hydrogen chloride gas, so that other impurities can be prevented from being introduced in a preparation process under the improper control of dosage and rate of the gas.

Construction of chiral 2-substituted octahydroindoles from cyclic ketones and nitroolefins bearing only one α-substituent

A dual catalytic system has been developed following the screening of a series of chiral primary amine catalysts and chiral phosphoric acid catalysts for the Michael addition of cyclic ketones to nitroolefins bearing only one α-substituent. The resulting γ-nitro ketones, which contain a substituent on the carbon connected to the nitro group, were formed in excellent yields (>80%) with high levels of stereoselectivity (up to 94:6 dr and 98% ee) when the reaction was performed in benzene at 0 °C with 10 mol% of the optimal amine/phosphoric acid combination (1:1) as a catalyst. Subsequent reduction of the nitro group followed by intramolecular reductive amination could afford optically active cis-octahydroindole analogues bearing a non-functional substituent at their 2-position.

NEW 2-SUBSTITUTED, 4-AMINO-THIAZOLO[4,5-D] PYRIMIDINES, USEFUL AS CHEMOKINE RECEPTOR ANTAGONISTS, ESP. CX3CR1

There are disclosed novel compounds of formula (I) wherein A, R1, R2, R3 and X are as defined in the specification, and pharmaceutically acceptable salts thereof, together with processes for their preparation, pharmaceutical compositions comprising them and their use in therapy. The compounds of formula (I) are CX3CR1 receptor antagonists and are thereby particularly useful in the treatment or prophylaxis of neurodegenerative disorders, demyelinating disease, atherosclerosis and pain.