16801-64-2

Basic information

• Product Name: 4-methyl-N-(4-oxo-cyclohexyl)benzenesulfonamide
• Synonyms: 4-methyl-N-(4-oxo-cyclohexyl)benzenesulfonamide
• CAS NO: 16801-64-2
• Molecular Weight: 267.349
• Mol File: 16801-64-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-methyl-N-(4-oxo-cyclohexyl)benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methyl-N-(4-oxo-cyclohexyl)benzenesulfonamide(16801-64-2)
• EPA Substance Registry System: 4-methyl-N-(4-oxo-cyclohexyl)benzenesulfonamide(16801-64-2)

Safety Data

• Hazardous Substances Data: 16801-64-2(Hazardous Substances Data)

Upstream product

• 131511-13-2 4-(N-benzylamino)cyclohexanone ethylene acetal 
• 98-59-9 p-toluenesulfonyl chloride 
• 80-30-8 N-cyclohexyl-p-toluenesulfonamide 

Relevant articles and documents

Organocatalytic Enantioselective Conia-Ene-Type Carbocyclization of Ynamide Cyclohexanones: Regiodivergent Synthesis of Morphans and Normorphans

Described herein is an organocatalytic enantioselective desymmetrizing cycloisomerization of arylsulfonyl-protected ynamide cyclohexanones, representing the first metal-free asymmetric Conia-ene-type carbocyclization. This method allows the highly efficient and atom-economical construction of a range of valuable morphans with wide substrate scope and excellent enantioselectivity (up to 97 % ee). In addition, such a cycloisomerization of alkylsulfonyl-protected ynamide cyclohexanones can lead to the divergent synthesis of normorphans as the main products with high enantioselectivity (up to 90 % ee). Moreover, theoretical calculations are employed to elucidate the origins of regioselectivity and enantioselectivity.