16806-93-2 Usage
Description
6,7-Dihydro-4(5H)-benzofuranone is a benzofuran derivative that consists of a fused benzene and furan ring. It is characterized by its clear yellow to brown color and can exist as a low melting solid or liquid. The standard molar enthalpy of formation for this compound has been measured using static bomb calorimetry and standard molar enthalpy of vaporization with Calvet microcalorimetry, allowing for the calculation of its standard molar enthalpy of formation in the gaseous phase.
Uses
Used in Pharmaceutical Industry:
6,7-Dihydro-4(5H)-benzofuranone is used as a key intermediate in the synthesis of various pharmaceutical compounds, particularly those containing the furacridone ring skeleton. Its unique structure and properties make it a valuable building block for the development of new drugs with potential therapeutic applications.
Used in Chemical Synthesis:
In the field of organic chemistry, 6,7-Dihydro-4(5H)-benzofuranone serves as a versatile intermediate for the synthesis of a wide range of organic compounds. Its ability to participate in various chemical reactions, such as electrophilic aromatic substitution and nucleophilic addition, makes it a useful component in the creation of complex organic molecules for research and industrial applications.
Synthesis Reference(s)
Tetrahedron, 51, p. 3087, 1995 DOI: 10.1016/0040-4020(95)00070-OTetrahedron Letters, 27, p. 1127, 1986 DOI: 10.1016/S0040-4039(00)84195-7
Check Digit Verification of cas no
The CAS Registry Mumber 16806-93-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,8,0 and 6 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 16806-93:
(7*1)+(6*6)+(5*8)+(4*0)+(3*6)+(2*9)+(1*3)=122
122 % 10 = 2
So 16806-93-2 is a valid CAS Registry Number.
InChI:InChI=1/C8H8O2/c9-7-2-1-3-8-6(7)4-5-10-8/h4-5H,1-3H2
16806-93-2Relevant articles and documents
A concise new synthesis of angular furanocoumarins: Angelicin, oroselone and oroselol
Lee
, p. 3087 - 3094 (1995)
An efficient synthesis of angular furanocoumarins has been carried out starting from dihydrobenzofuran derivatives.
A Convenient Synthesis of 4-tert-Butyl-5-benzofuranols and Dihydrobenzofuranols
Zambias, Robert A.,Caldwell, Charles G.,Kopka, Ihor E.,Hammond, Milton L.
, p. 4135 - 4137 (1988)
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Preparation method of polysubstituted furan compound
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Paragraph 0003, (2021/02/10)
The invention discloses a preparation method of a polysubstituted furan compound, which comprises the following steps: by using a carbonyl compound with an electron withdrawing group at the alpha position and dichloroolefin as raw materials, reacting under alkaline conditions to obtain a 2, 3-disubstituted furan compound and a 2, 3, 5-trisubstituted furan compound. The method has the advantages ofno need of transition metal catalysis, strong substrate applicability, cheap and easily available raw materials, simple operation, high efficiency and wide application prospect.
Transition-Metal-Free Approach to Polysubstituted Furans
You, Changming,Zhang, Zhenming,Tu, Yongliang,Tang, Hong,Wang, Yuanfeng,Long, Da,Zhao, Junfeng
, p. 3902 - 3910 (2020/03/23)
A convenient and straightforward strategy for the synthesis of 2,3-disubstituted and 2,3,5-trisubstituted furans via a base-promoted domino reaction of β-keto compounds with vinyl dichlorides is described. This transition-metal-free approach proceeds under operationally simple reaction conditions featuring easily available starting materials, a broad substrate scope, and good functional group tolerance.
