16807-11-7 Usage
Description
1-Bromo-9H-carbazole is a chemical compound belonging to the carbazole family, characterized by the presence of a bromine atom at the 1-position and a 9H-carbazole core. It exhibits a white to yellow powder or crystalline appearance and is widely recognized for its utility in various chemical and pharmaceutical applications.
Uses
Used in Pharmaceutical Industry:
1-Bromo-9H-carbazole serves as a pharmaceutical intermediate, playing a crucial role in the synthesis of various drug molecules. Its unique chemical structure allows it to be a versatile building block for the development of new medications with potential therapeutic benefits.
Used in Organic Synthesis:
In the field of organic synthesis, 1-bromo-9H-carbazole is employed as an intermediate for the preparation of a range of organic compounds. Its reactivity and functional group compatibility make it a valuable component in the creation of complex organic molecules for various applications, including materials science, agrochemicals, and specialty chemicals.
As a research chemical, 1-bromo-9H-carbazole contributes to the advancement of scientific knowledge and the discovery of new chemical reactions and processes. Its applications in both the pharmaceutical and organic synthesis industries highlight its importance as a key intermediate in the development of innovative products and technologies.
Preparation
A 1-Bromo-9H-carbazole is synthesized as follows：Under noble gas protection, by 3,6- bis- Tert-butyl carbazole is dissolved in 1,2- dichloroethanes, adds hydrobromic acid, controlling reaction temperature to be slowly added dropwise hydrogen peroxide, dropping is completely Overnight, reactant liquor is washed, and separates organic layer for natural temperature reaction, is dried, and adds methyl alcohol dispersion, obtains the tertiary fourth of bromo- 3, the 6- of 1- bis- Base carbazole；Then 1- bromo- 3,6- di-t-butyl carbazole and isopropanol solvent are added in reaction bulb, controlling reaction temperature slowly adds Enter alchlor reaction, add water after terminating terminating reaction, through extraction, organic layer sodium hydrate aqueous solution is washed, and is dried overnight, concentrate Obtain crude product, methylene chloride-methanol mixed solvent is recrystallized to give product 1-Bromo-9H-carbazole.Production method of 1-bromocarbazole
Check Digit Verification of cas no
The CAS Registry Mumber 16807-11-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,8,0 and 7 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 16807-11:
(7*1)+(6*6)+(5*8)+(4*0)+(3*7)+(2*1)+(1*1)=107
107 % 10 = 7
So 16807-11-7 is a valid CAS Registry Number.
16807-11-7Relevant articles and documents
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Drake,N.L. et al.
, p. 1026 - 1030 (1962)
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Halogenated method of aromatic compound
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Paragraph 0091-0094; 0186-0188; 0195-0197, (2021/11/10)
The invention belongs to the field of organic synthesis, and particularly relates to synthesis of aromatic halogens, in particular to arylamine. The invention discloses a synthesis method of a corresponding ortho-halogenated product from aromatic compounds such as carbazole and phenol. The method comprises the following steps: adding a metal sulfonate salt catalyst, aromatic amine, carbazole, phenol and other hydrogen - heteroatom-containing aromatic compound reaction substrates, a halogenation reagent and a reaction solvent at a specific reaction temperature. After the drying agent is dried, the yield of the reaction product and the nuclear magnetic characterization determining structure are determined by column chromatography. The reaction product yield is determined by gas chromatography. By adopting the method, under the cheap metal salt catalyst, a plurality of ortho-substituted brominated and chloro products can be obtained with moderate to excellent yield.
ORGANOMETALLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME
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Paragraph 0257-0259, (2017/02/24)
An organometallic compound represented by Formula 1: wherein, in Formula 1, groups and variables are the same as described in the specification.
