168112-89-8

Basic information

• Product Name: (S)-2-Amino-1-(3-chloro-phenyl)-ethanol
• Synonyms: (S)-2-Amino-1-(3-chloro-phenyl)-ethanol;(1S)-2-Amino-1-(3-chlorophenyl)ethanol;a-(aMinoMethyl)-3-chloro-;(S)-alpha-(Aminomethyl)-3-chlorobenzenemethanol;[(S)-2-(3-Chlorophenyl)-2-hydroxyethyl]amine
• CAS NO: 168112-89-8
• Molecular Formula: C₈H₁₀ClNO
• Molecular Weight: 171.62
• Product Categories: pharmacetical;API intermediates
• Mol File: 168112-89-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 319.809°C at 760 mmHg
• Flash Point: 147.215°C
• Appearance: /
• Density: 1.261g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.587
• CAS DataBase Reference: (S)-2-Amino-1-(3-chloro-phenyl)-ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-Amino-1-(3-chloro-phenyl)-ethanol(168112-89-8)
• EPA Substance Registry System: (S)-2-Amino-1-(3-chloro-phenyl)-ethanol(168112-89-8)

Safety Data

• Hazardous Substances Data: 168112-89-8(Hazardous Substances Data)

Usage

General Description

(S)-2-Amino-1-(3-chloro-phenyl)-ethanol, also known as 3-(Chloromethyl)benzylamine, is a chemical compound with the molecular formula C8H10ClNO. It is a chiral amine containing both an amine group and a hydroxyl group, making it a versatile building block in organic synthesis. (S)-2-Amino-1-(3-chloro-phenyl)-ethanol has been used in the production of pharmaceuticals, agrochemicals, and specialty chemicals. It also has potential applications in the synthesis of bioactive compounds and as a chiral ligand in asymmetric catalysis. Additionally, (S)-2-Amino-1-(3-chloro-phenyl)-ethanol has been studied for its potential as a therapeutic agent in the treatment of neurological disorders and cancer. Overall, this compound has a wide range of potential applications in the field of organic chemistry and pharmaceutical research.

InChI:InChI=1/C8H10ClNO/c9-7-3-1-2-6(4-7)8(11)5-10/h1-4,8,11H,5,10H2/t8-/m1/s1

Upstream product

• 204972-89-4 (S)-(+)-1-(3-Chlorophenyl)-2-(p-tolylsulfonyloxy)ethanol 

Downstream Products

• 726206-23-1 6-{4-[(S)-2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-2-oxo-1,2-dihydro-pyridin-3-yl}-3,5-dihydro-1H-benzo[1,2-d;4,5-d]diimidazol-2-one 
• 847776-33-4 (S)-2-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-3-(1-tert-butyloxycarbonyl-4-methyl-6-morpholin-4-yl-1H-benzoimidazol-2-yl)-but-2-enedioic acid diethyl ester 
• 936935-52-3 4-[(S)-2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-3-[6-(7-ethyl-2,7-diaza-spiro[4.4]non-2-yl)-4-methyl-1H-benzoimidazol-2-yl]-1H-pyridin-2-one 
• 936935-53-4 3-[6-(8-benzyl-2,8-diaza-spiro[5.5]undec-2-yl)-4-methyl-1H-benzoimidazol-2-yl]-4-[(S)-2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-1H-pyridin-2-one 
• 936935-54-5 4-[(S)-2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-3-[6-(2,8-diaza-spiro[5.5]undec-2-yl)-4-methyl-1H-benzoimidazol-2-yl]-1H-pyridin-2-one 
• 936939-80-9 (S)-1-(3-chloro-phenyl)-2-(3-[1,3]dioxolan-2-yl-2-methoxy-pyridin-4-ylamino)-ethanol 
• 1008445-21-3 2-{4-[(S)-2-(3-Chloro-phenyl)-2-hydroxy-ethylamino]-2-oxo-1,2-dihydro-pyridin-3-yl}-6-[(S)-1-(tetrahydro-furan-2-yl)methyl]-1H-1,3,6-triaza-s-indacene-5,7-dione 
• 667402-57-5 4-trifluoromethanesulfonyloxy-3-(1-tert-butyloxycarbonyl-4-methyl-6-morpholin-4-yl-1H-benzoimidazol-2-yl)-1,5-dihydro-pyrrol-2-one 
• 1054315-42-2 (S)-4-(2-(3-chlorophenyl)-2-hydroxyethylamino)-3-(6-(1-(3-fluoropropyl)piperidin-4-yl)-4-methyl-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one 
• 1054315-41-1 (S)-4-(2-(3-chlorophenyl)-2-hydroxyethylamino)-3-(6-(1-(2-methoxyethyl)piperidin-4-yl)-4-methyl-1H-benzo[d]imidazo1-2-yl)pyridin-2(1H)-one 
• 1054315-40-0 (S)-4-(2-(3-chlorophenyl)-2-hydroxyethylamino)-3-(4-methyl-6-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one 
• 741244-97-3 C₃₀H₃₅ClN₆O₄ 

Relevant articles and documents

Tricyclic compound derivatives useful in the treatment of neoplastic diseases, inflammatory disorders and immunomodulatory disorders

Provided are compounds of the formula (I): or a stereoisomer, tautomer, salt, hydrate or prodrug thereof that modulate tyrosine kinase activity, compositions comprising the compounds and methods of their use.

Application of optically active 1,2-diol monotosylates for synthesis of β-azido and β-amino alcohols with very high enantiomeric purity. Synthesis of enantiopure (R)-octopamine, (R)-tembamide and (R)-aegeline

A very convenient and highly efficient synthesis of near enantiopure β-azido and β-amino alcohols including biologically active substances such as (R)-octopamine, (R)-tembamide and (R)-aegeline from optically active 1,2-diol monotosylates is reported.