168213-37-4

Basic information

• Product Name: 1,4-di(hex-1-yn-1-yl)benzene
• Synonyms: 1,4-di(hex-1-yn-1-yl)benzene
• CAS NO: 168213-37-4
• Molecular Weight: 238.373
• Mol File: 168213-37-4.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 1,4-di(hex-1-yn-1-yl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-di(hex-1-yn-1-yl)benzene(168213-37-4)
• EPA Substance Registry System: 1,4-di(hex-1-yn-1-yl)benzene(168213-37-4)

Safety Data

• Hazardous Substances Data: 168213-37-4(Hazardous Substances Data)

Upstream product

• 624-38-4 para-diiodobenzene 
• 693-02-7 hex-1-yne 
• 58177-69-8 n-butylethynylmagnesium chloride 
• 2425-81-2 phen-1,4-ylenbis(magnesiumbromid) 
• 133381-92-7 hexynylzinc bromide 
• 623-03-0 4-Cyanochlorobenzene 

Downstream Products

• 167319-26-8 1-ethynyl-2,5-dihexyl-4-iodobenzene 
• 194015-15-1 [2-(2,5-dihexyl-4-iodophenyl)ethynyl](trimethyl)silane 
• 162715-91-5 1,4-dihexyl-2,5-diiodobenzene 

Relevant articles and documents

In Situ Generation of Alkynylzinc and Its Subsequent Negishi Reaction in a Flow Reactor

A highly efficient and convenient Negishi cross-coupling reaction has been developed for the synthesis of unsymmetrical alkynes and enynes in a continuous-flow process. The reaction proceeds through an in situ generated alkynylzinc reagent by the reaction of lithium acetylide with zinc halide at room temperature followed by a cross-coupling reaction with aryl or vinyl iodides. The notable features of this work compared to the conventional benchtop method are mild reaction conditions, good to excellent yields, broad functional-group compatibility, short residence time (73 sec) and especially desilylation of TMS group with the residence time of only 10.5 sec.

Synthesis of functionalized alkynes via palladium-catalyzed Sonogashira reactions

A highly efficient protocol for the copper and phosphine free Sonogashira cross-coupling reactions of aryl iodides with terminal alkynes under aerobic conditions has been developed. Using 1 mol % of the palladium-bis(oxazoline) complex, Pd-BOX A, in the p

Process for preparing alkynyl-substituted aromatic and heterocyclic compounds

Mono- and disubstituted aryl or heterocyclic acetylenes are produced by a process comprising reacting an aryl nitrile with an alkynylzinc compound, a bis-alkynylzinc compound, or an alkynylmagnesium compound, in the presence of a nickel/phosphine catalyst.