16839-98-8 Usage
Description
Noratropine, a metabolite of Atropine (A794625), is derived from the chemical breakdown of Atropine in the body. It is one of the two metabolites, along with apoatropine, that have been identified in rat urine. Noratropine possesses unique chemical properties that make it a potential candidate for various applications across different industries.
Uses
Used in Pharmaceutical Industry:
Noratropine is used as an active pharmaceutical ingredient for its potential therapeutic effects. As a metabolite of Atropine, it may exhibit similar or distinct pharmacological properties that can be harnessed for the development of new drugs or therapies.
Used in Research and Development:
In the field of scientific research, Noratropine is used as a subject of study to better understand the metabolic pathways of Atropine and its potential effects on the human body. This knowledge can contribute to the development of more effective drugs and treatments.
Used in Toxicology Studies:
Noratropine is used as a biomarker in toxicology studies to assess the exposure to Atropine or related compounds. Understanding the presence and levels of Noratropine in biological samples can help in determining the safety and potential risks associated with Atropine exposure.
Used in Quality Control and Analysis:
In the pharmaceutical and chemical industries, Noratropine can be used as a reference compound for quality control and analytical purposes. It can help in the development of accurate and reliable methods for the detection, quantification, and characterization of Atropine and its metabolites in various samples.
Check Digit Verification of cas no
The CAS Registry Mumber 16839-98-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,8,3 and 9 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 16839-98:
(7*1)+(6*6)+(5*8)+(4*3)+(3*9)+(2*9)+(1*8)=148
148 % 10 = 8
So 16839-98-8 is a valid CAS Registry Number.
InChI:InChI=1/C16H21NO3/c18-9-15(16(19)20)11-3-1-2-10(6-11)12-7-13-4-5-14(8-12)17-13/h1-3,6,12-15,17-18H,4-5,7-9H2,(H,19,20)
16839-98-8Relevant articles and documents
Preparation of noratropine by oxidative n-demethylation of atropine
Van Der Meer,Hundt
, p. 408 - 408 (1983)
-
MEANS AND METHODS FOR THE N-DEALKYLATION OF AMINES
-
Page/Page column 21, (2017/11/10)
The invention relates to improved means and methods for N- dealkylation of alkylated amines. Provided is a method for the catalytic N- dealkylation of an N-alkylated amine substrate, comprising incubating said amine substrate in a suitable solvent in the
Studies on the oxidative N-demethylation of atropine, thebaine and oxycodone using a FeIII-TAML catalyst
Do Pham, Duy D.,Kelso, Geoffrey F.,Yang, Yuanzhong,Hearn, Milton T.W.
, p. 1399 - 1409 (2014/03/21)
The reaction pathway and selectivity of the oxidative N-demethylation of the alkaloid atropine with H2O2 using a Fe III-TAML catalyst has been investigated. The conversion of atropine in ethanol with aqueous H2O
Further investigation of the N-demethylation of tertiary amine alkaloids using the non-classical Polonovski reaction
Thavaneswaran, Shanti,Scammells, Peter J.
, p. 2868 - 2871 (2007/10/03)
The iron salt-mediated Polonovski reaction efficiently N-demethylates certain opiate alkaloids. In this process, the use of the hydrochloride salt of the tertiary N-methyl amine oxide was reported to give better yields of the desired N-demethylated product. Herein, we report further investigation into the use of N-oxide salts in the iron salt-mediated Polonovski reaction. An efficient approach for the removal of iron salts that greatly facilitates isolation and purification of the N-nor product is also described.
