1684-14-6Relevant articles and documents
Green and efficient synthesis of quinoxaline derivatives via ceric ammonium nitrate promoted and in situ aerobic oxidation of α-hydroxy ketones and α-keto oximes in aqueous media
Shaabani, Ahmad,Maleki, Ali
, p. 79 - 81 (2008)
The direct conversion of α-hydroxy ketones and α-keto oximes into quinoxaline derivatives in the presence of a catalytic amount of ceric ammonium nitrate via metal-catalyzed aerobic oxidation followed by in situ trapping with aromatic 1,2-diamines in water as a green and efficient reaction media, is reported.
Comprehensive experimental investigation of mechanically induced 1,4-diazines synthesis in solid state
Oliveira, Paulo F.M.,Haruta, Naoki,Chamayou, Alain,Guidetti, Brigitte,Baltas, Michel,Tanaka, Kazuyoshi,Sato, Tohru,Baron, Michel
, p. 2305 - 2310 (2017)
Compared mechanosynthesis of two condensed 1,4-diazines were investigated in ball milling conditions from o-phenylenediamine. 13C CP-MAS NMR revealed a hemiaminal intermediate for dibenzo[a,c]phenazine synthesis accumulated under mechanical act
2-Iodo benzoic acid: An unconventional precursor for the one pot multi-component synthesis of quinoxaline using organo Cu (II) catalyst
Saha, Bittu,Mitra, Bijeta,Brahmin, Dhiraj,Sinha, Biswajit,Ghosh, Pranab
, p. 3657 - 3663 (2018)
This is the first reported, unconventional, efficient strategy for the synthesis of quinoxaline from 2 to iodo benzoic acid and sodium azide in presence of organo Cu (II) catalyst. Herein, a very simple, versatile one pot multi-component protocol for the synthesis of biologically active compound, quinoxaline has been described via Schmidt reaction and the nucleophilic substitution reaction. The isolated compounds were characterized by 1H NMR, 13C NMR. Our reported organo catalyst was characterized by single crystal XRD, SEM.
Synthesis, characterization and catalytic activity of oxovanadium(IV) complexes of heterocyclic acid hydrazones
Pandey, Manju,Sunaja Devi,Sreeja
, p. 4135 - 4137 (2015)
Two acid hydrazones, furan-2-carbaldehyde nicotinic hydrazone (L1) and furan-2-carbaldehyde benzhydrazone (L2) have been synthesized and they are characterized by elemental analysis, IR, NMR and UV spectral analysis. Oxovanadium(IV) complexes of these two
Biomass into chemicals: One-pot two- and three-step synthesis of quinoxalines from biomass-derived glycols and 1,2-dinitrobenzene derivatives using supported gold nanoparticles as catalysts
Climent,Corma,Hernandez,Hungria,Iborra,Martinez-Silvestre
, p. 118 - 129 (2012)
An efficient and selective one-pot two-step method, for the synthesis of quinoxalines by oxidative coupling of vicinal diols with 1,2-phenylenediamine derivatives, has been developed by using gold nanoparticles supported on nanoparticulated ceria (Au/CeO2) or hydrotalcite (Au/HT) as catalysts and air as oxidant, in the absence of any homogeneous base. Reaction kinetics shows that the reaction controlling step is the oxidation of the diol to α-hydroxycarbonyl compound. Furthermore, a one-pot three-step synthesis of 2-methylquinoxaline starting from 1,2-dinitrobenzene and 1,2-propanediol has been successfully carried out with 98% conversion and 83% global yield to the final product.
Tungstophosphoric acid/mesoporous silicas as suitable catalysts in quinoxaline synthesis
Langer, Peter,Luque, Rafael,Palermo, Valeria,Pizzio, Luis R.,Romanelli, Gustavo P.,Sosa, Alexis A.
, (2021/12/16)
Quinoxalines and their derivatives are of great value in the chemical and biological sciences. These compounds are found in dyes, agrochemicals, and are used as building blocks of drugs for the treatment of different diseases. Quinoxalines and their deriv
One-pot cascade synthesis of α-diketones from aldehydes and ketones in water by using a bifunctional iron nanocomposite catalyst
Song, Tao,Zhou, Xin,Wang, Xiaoxue,Xiao, Jianliang,Yang, Yong
, p. 1955 - 1959 (2021/03/26)
A new methodology for the synthesis of α-diketones was reportedviaa one-pot cascade process from aldehydes and ketones catalyzed by a bifunctional iron nanocomposite using H2O2as a green oxidant in water. The one-pot strategy showed excellent catalytic stability, comprehensive suitability of substrates and important practical utility for directly synthesizing biologically active and medicinally valuable N-heterocyclesviaan intermittent process.
In water organic synthesis: Introducing itaconic acid as a recyclable acidic promoter for efficient and scalable synthesis of quinoxaline derivatives at room temperature
Tamuli, Kashyap J.,Nath, Shyamalendu,Bordoloi, Manobjyoti
supporting information, p. 983 - 1002 (2021/02/27)
Substituted quinoxaline derivatives are traditionally synthesized by co-condensation of various starting materials. Herein, we describe a novel environmentally benign in water synthetic route for the synthesis of structurally and electronically diverse ninety quinoxalines with readily available substituted o-phenylenediamine and 1,2-diketones using cheap and biodegradable itaconic acid as a mild acid promotor in 1 hours. The reaction is performed at room temperature, which proceeds through cyclo-condensation reaction followed by obtaining the aforesaid nitrogen-containing heterocyclic adducts without performing the column chromatography up to 96% total yields. The simplicity, high efficiency, and reusable of the catalyst merits this reaction condition as “green synthesis” which enables it to be useful in synthetic transformations upto gram scale level.
