168482-23-3 Usage
Description
SHU-9119 is a dual-functioning compound that acts as an agonist for melanocortin receptor 1 (MC1R) and an antagonist for melanocortin receptor 4 (MC4R). It is characterized by its ability to induce cAMP formation in cells expressing human MC1R and inhibit cAMP formation in cells expressing human MC4R. SHU-9119 has been shown to influence food intake, body weight, fat mass, and lean mass in both rats and mice, with associated effects on blood glucose, insulin, and leptin levels.
Uses
Used in Pharmaceutical Industry:
SHU-9119 is used as a pharmacological agent for the treatment of obesity and related metabolic disorders. Its dual action on MC1R and MC4R receptors allows for the modulation of food intake, body weight, and fat mass, making it a potential therapeutic candidate for obesity management.
Used in Research Applications:
SHU-9119 is used as a research tool for studying the roles of melanocortin receptors in various physiological processes, including energy balance, food intake, and body weight regulation. Its ability to act on both MC1R and MC4R receptors makes it a valuable compound for investigating the complex interactions between these receptors and their downstream signaling pathways.
Used in Drug Development:
SHU-9119 serves as a lead compound for the development of novel therapeutics targeting melanocortin receptors. Its unique properties as an agonist for MC1R and antagonist for MC4R provide a foundation for designing new drugs that can effectively treat obesity and related metabolic disorders with minimal side effects.
Used in Endocrinology:
SHU-9119 is used as a diagnostic tool in endocrinology to assess the functionality of melanocortin receptors and their role in regulating glucose, insulin, and leptin levels. This can help in understanding the underlying mechanisms of obesity and related metabolic disorders, as well as in the development of personalized treatment strategies.
Check Digit Verification of cas no
The CAS Registry Mumber 168482-23-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,8,4,8 and 2 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 168482-23:
(8*1)+(7*6)+(6*8)+(5*4)+(4*8)+(3*2)+(2*2)+(1*3)=163
163 % 10 = 3
So 168482-23-3 is a valid CAS Registry Number.
InChI:InChI=1/C54H71N15O9/c1-3-4-15-40(63-31(2)70)48(73)68-45-27-46(71)59-21-10-9-17-41(50(75)69-53(78)44(67-52(45)77)26-36-29-58-30-62-36)65-51(76)43(25-35-28-61-39-16-8-7-14-37(35)39)66-49(74)42(18-11-22-60-54(56)57)64-47(72)38(55)24-32-19-20-33-12-5-6-13-34(33)23-32/h5-8,12-14,16-17,19-20,23,29-30,35-36,38,40,42-45,61H,3-4,9-11,15,18,21-22,24-28,55H2,1-2H3,(H,59,71)(H,63,70)(H,64,72)(H,65,76)(H,66,74)(H,67,77)(H,68,73)(H4,56,57,60)(H,69,75,78)/b41-17+/t35?,36?,38-,40+,42+,43+,44+,45+/m1/s1
