168553-64-8

Basic information

• Product Name: (S)-3-Benzyloxy-2-methyl-2-(2-trimethylsilanyl-ethanesulfonylamino)-propionic acid
• Synonyms: (S)-3-Benzyloxy-2-methyl-2-(2-trimethylsilanyl-ethanesulfonylamino)-propionic acid
• CAS NO: 168553-64-8
• Molecular Weight: 373.546
• Mol File: 168553-64-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (S)-3-Benzyloxy-2-methyl-2-(2-trimethylsilanyl-ethanesulfonylamino)-propionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-Benzyloxy-2-methyl-2-(2-trimethylsilanyl-ethanesulfonylamino)-propionic acid(168553-64-8)
• EPA Substance Registry System: (S)-3-Benzyloxy-2-methyl-2-(2-trimethylsilanyl-ethanesulfonylamino)-propionic acid(168553-64-8)

Safety Data

• Hazardous Substances Data: 168553-64-8(Hazardous Substances Data)

Upstream product

• 168553-63-7 2-Trimethylsilanyl-ethanesulfonic acid ((S)-1-benzyloxymethyl-1-methyl-2-trityloxy-ethyl)-amide 
• 168553-71-7 (S)-2-methyl-1-(2-trimethylsilanyl-ethanesulfonyl)-2trityloxymethyl-aziridine 
• 106018-85-3 2-trimethylsilanyl-ethanesulfonyl chloride 
• 168553-72-8 2-Trimethylsilanyl-ethanesulfonic acid ((R)-2-benzyloxy-1-hydroxymethyl-1-methyl-ethyl)-amide 

Downstream Products

• 168553-66-0 (2R,3S)-2-[(S)-3-Benzyloxy-2-methyl-2-(2-trimethylsilanyl-ethanesulfonylamino)-propionylamino]-3-hydroxy-butyric acid methyl ester 
• 819081-56-6 2-((S)-1-Amino-2-benzyloxy-1-methyl-ethyl)-5-methyl-oxazole-4-carboxylic acid methylamide 
• 819081-59-9 2-[(S)-1-((S)-2-Amino-3-benzyloxy-2-methyl-propionylamino)-2-benzyloxy-1-methyl-ethyl]-5-methyl-oxazole-4-carboxylic acid methylamide 
• 171011-87-3 2-<(1S)-2-(Benzyloxy)-1-<<(2S)-3-(benzyloxy)-2-methyl-2-<<<2-(trimethylsilyl)ethyl>sulfonyl>amino>propionyl>amino>-1-methylethyl>-5-methyloxazole-4-carboxylic acid methylamide 
• 171011-92-0 2-<(1S)-3-(Benzyloxy)-1-methyl-1-<(3-phenyl-propionyl)amino>ethyl>-5-methyloxazole-4-carboxylic acid methylamide 
• 171011-99-7 2-<(1S)-2-(Benzyloxy)-1-methyl-1-<<<2-(trimethylsilyl)ethyl>sulfonyl>amino>ethyl>-5-methyloxazole-4-carboxylic acid methylamide 
• 171011-86-2 2-<(1S)-2-(Benzyloxy)-1-methyl-1-<<<2-(trimethylsilyl)ethyl>sulfonyl>amino>ethyl>-5-methyloxazole-4-carboxylic acid methyl ester 
• 819081-93-1 2-{(S)-1-[(S)-2-((S)-2-Amino-3-benzyloxy-2-methyl-propionylamino)-3-benzyloxy-2-methyl-propionylamino]-2-benzyloxy-1-methyl-ethyl}-5-methyl-oxazole-4-carboxylic acid methylamide 
• 171011-89-5 2-<(1S)-2-(Benzyloxy)-1-<<(2S)-3-(benzyloxy)-2-<<(3S)-3-(benzyloxy)-2-methyl-2-<(3-phenylpropionyl)amino>propionyl>amino>-2-methylpropionyl>amino>-1-methylethyl>-5-methyloxazole-4-carboxylic acid methylamide 
• 171011-98-6 (R)-2-[(S)-3-Benzyloxy-2-methyl-2-(2-trimethylsilanyl-ethanesulfonylamino)-propionylamino]-3-oxo-butyric acid methyl ester 
• 171011-88-4 2-<(1S)-2-(Benzyloxy)-1-<<(2S)-3-(benzyloxy)-2-<<(3S)-(benzyloxy)-2-methyl-2-<<<2-(trimethylsilyl)ethyl>sulfonyl>amino>propionyl>amino>-2-methyl-propionyl>amino>-1-methylethyl>-5-methyloxazole-4-carboxylic acid methylamide 
• 3398-40-1 (S)-(+)-2-amino-2-methyl-3-hydroxypropanoic acid 

Relevant articles and documents

From Aziridines to Oxazolines and Thiazolines: The Heterocyclic Route to Thiangazole

Since its isolation in 1991, the polyazole natural product thiangazole has become a popular target for total synthesis due to its challenging array of heterocyclic segments and its reported potent antiviral activity. The synthetic activity toward thiangazole is reviewed and a novel approach that takes advantage of aziridine and oxazoline intermediates en route to thiazolines is presented.