168626-74-2 Usage
Synthesis
Thionyl chloride (10.4 g, 87.4 mmol) was added to a mixture of biphenyl-2-carboxylic acid (15.0 g, 75.7 mmol) and DMF (0.28 g, 3.83 mmol) in toluene (72 mL) at an internal temperature of 40 oC. The mixture was stirred at this temperature for approximately 2 h. After completion of the reaction, the mixture was concentrated to dryness at 60 oC. The resultant residue was then diluted with toluene (36 mL) and concentrated to dryness at 60 oC, and the process was repeated again to give biphenyl-2- carbonyl chloride as an oil. Acetone (100 mL) was added to the oil, and 4-amino benzoic acid (10.4 g, 75.8 mmol) and N,N-dimethylaniline (10.1 g, 83.3 mmol) were added to the resultant solution at 25 oC. The mixture was stirred at this temperature for approximately 2 h. Water (100 mL) was then poured into the mixture, and it was stirred at 25 oC for more than 1 h. The resultant crystals were collected by fifiltration and dissolved in DMF (100 mL) at 25 oC. The solution was then fifiltered to remove insoluble materials, water (100 mL) was poured into the fifiltrate, and it was stirred at 25 oC for approximately 2 h. The resultant crystals were collected by fifiltration and dried at 40 oC to give the amide as white crystals (22.7 g, 95%). Reference: Tsunoda, T.; Yamazaki, A.; Mase, T.; Sakamoto, S. Org. Process Res. Dev. 2005, 9, 593–598.
Check Digit Verification of cas no
The CAS Registry Mumber 168626-74-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,8,6,2 and 6 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 168626-74:
(8*1)+(7*6)+(6*8)+(5*6)+(4*2)+(3*6)+(2*7)+(1*4)=172
172 % 10 = 2
So 168626-74-2 is a valid CAS Registry Number.
168626-74-2Relevant articles and documents
Palladium Supported on Silk Fibroin for Suzuki–Miyaura Cross-Coupling Reactions
Albano, Gianluigi,Farinola, Gianluca M.,Lo Presti, Marco,Milella, Antonella,Omenetto, Fiorenzo G.,Rizzo, Giorgio
, p. 6992 - 6996 (2020/11/30)
Silk fibroin supported Pd (Pd/SF) has been prepared and used as catalyst in Suzuki–Miyaura cross-coupling reactions in water/ethanol (4:1 v/v) mixture. The reactions proceed rapidly with aryl iodides and boronic acids with different electronic properties using low metal loading (0.38 mol-%). Pd/SF exhibits better recyclability compared to other biopolymer-supported Pd catalysts, up to nineteen cycles without loss of activity.
A scalable process for the synthesis of 2-methyl-1,4,5,6- tetrahydroimidazo[4,5-d][1]benzazepine monohydrate and 4-[(biphenyl-2- ylcarbonyl)amino]benzoic acid: Two new key intermediates for the synthesis of the AVP antagonist conivaptan hydrochloride
Tsunoda, Takashi,Yamazaki, Atsuki,Mase, Toshiyasu,Sakamoto, Shuichi
, p. 593 - 598 (2012/12/25)
A process for the multikilogram synthesis of the dual vasopressin-receptor antagonist, conivaptan hydrochloride, has been developed. This method relies on the introduction of operationally simple chemistry during the final stages of the process when two k
TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS
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, (2008/06/13)
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