16898-52-5

Basic information

• Product Name: 1,3-Bis(4-piperidyl)propane
• Synonyms: 1,3-BIS(4-PIPERIDYL)PROPANE 97%;1,3-DI-4-PIPERIDYLPROPANE 98%;4,4-TRIMETHYLENEDIPIPERIDINE 98%;1,3-Bis(4-piperidino)propane, 97+%;1,3-Bis(4-piperidyl)propane, tech., 95%;1,3-Bis(4-piperidino)propane;1,3-Di(4-piperidinyl)propane;4,4'-(1,3-Propanediyl)dipiperidine
• CAS NO: 16898-52-5
• Molecular Formula: C₁₃H₂₆N₂
• Molecular Weight: 210.36
• EINECS: 240-941-6
• Product Categories: API intermediates;Building Blocks;Heterocyclic Building Blocks;Piperidines
• Mol File: 16898-52-5.mol
• Article Data: 3

Chemical Properties

• Melting Point: 65-68.5 °C(lit.)
• Boiling Point: 327°C
• Flash Point: 327°C
• Appearance: /
• Density: 0.9578 (rough estimate)
• Vapor Pressure: 0.00306mmHg at 25°C
• Refractive Index: 1.5032 (estimate)
• PKA: 10.99±0.10(Predicted)
• Water Solubility: almost transparency
• Sensitive: Hygroscopic
• BRN: 111615
• CAS DataBase Reference: 1,3-Bis(4-piperidyl)propane(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Bis(4-piperidyl)propane(16898-52-5)
• EPA Substance Registry System: 1,3-Bis(4-piperidyl)propane(16898-52-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• TSCA: Yes
• HazardClass: IRRITANT
• Hazardous Substances Data: 16898-52-5(Hazardous Substances Data)

Usage

Description

1,3-Bis(4-piperidyl)propane, also known as 4,4'-Trimethylenedipiperidine, is an organic compound that serves as a key monomer in the synthesis of various polymers and frameworks. It possesses a unique structure with two piperidine rings connected by a trimethylene bridge, which allows for versatile chemical reactions and applications.

Uses

Used in Polymer Synthesis:
1,3-Bis(4-piperidyl)propane is used as a monomer in the synthesis of hyperbranched copolymers from commercially available monomers such as divinylsulfone, 4,4'-trimethylenedipiperidine, and N-ethylenediamine. These copolymers have potential applications in various fields due to their unique properties, such as high molecular weight, low polydispersity, and tunable functionalities.
Used in Cadmium-Organic Frameworks:
1,3-Bis(4-piperidyl)propane is used as a building block in the synthesis of twoand three-dimensional cadmium-organic frameworks. These frameworks have potential applications in gas storage, catalysis, and sensing due to their high porosity, tunable pore sizes, and functionalizable surfaces.
Used in Polythioamide Formation:
1,3-Bis(4-piperidyl)propane undergoes the Willgerodt-Kindler reaction, a one-pot polycondensation with dialdehydes in the presence of sulfur, to form polythioamides. These polythioamides have potential applications in various fields, such as pharmaceuticals, materials science, and chemical sensors, due to their unique properties, such as high thermal stability, good film-forming ability, and tunable chemical reactivity.

Flammability and Explosibility

Notclassified

InChI:InChI=1/C13H26N2/c1-3-8-14(9-4-1)12-7-13-15-10-5-2-6-11-15/h1-13H2

Upstream product

• 17252-51-6 1,3-di(4-pyridyl)propane 
• 638563-17-4 ((CH₃O)2C₆H₂(NO₂)CH₂OCOC₅H₉NCH₂)2CH₂ 
• 100-43-6 4-vinylpyridine 
• 108-89-4 picoline 
• 181885-13-2 C₂₉H₃₆N₄O₈ 

Downstream Products

• 18073-84-2 1,3-bispropane 
• 159762-85-3 N,N'-Bis(5-phenoxy-3,3aλ⁴,4-trithia-1,6-diazapentalen-2-yl)-4,4'-(1,3-propandiyl)dipiperidin 
• 797805-10-8 [6-(4-{3-[1-(6-benzyloxycarbonylaminohexanoyl)piperidin-4-yl]propyl}piperidin-1-yl)-6-oxohexyl]carbamic acid benzyl ester 
• 797805-23-3 6-(2-methoxybenzylamino)-1-[4-(3-{1-[6-(2-methoxybenzylamino)hexanoyl]piperidin-4-yl}propyl)piperidin-1-yl]hexan-1-one 
• 797804-97-8 6-[ethyl-(2-methoxy-benzyl)-amino]-1-{4-[3-(1-{6-[ethyl-(2-methoxy-benzyl)-amino]-hexanoyl}-piperidin-4-yl)-propyl]-piperidin-1-yl}-hexan-1-one 
• 179682-17-8 4-(3-{1-[(S)-4-Methoxycarbonyl-4-(4-propyl-benzenesulfonylamino)-butyryl]-piperidin-4-yl}-propyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 1052175-17-3 N,N-bis(4-cyanobenzyl)-4,4'-propylenebispiperidine 
• 638563-17-4 ((CH₃O)2C₆H₂(NO₂)CH₂OCOC₅H₉NCH₂)2CH₂ 

Related news

Molecular structure and vibrational spectra of 1,3-bis(4-piperidyl)propane by quantum chemical calculations08/04/2019

The infrared and Raman spectra of 1,3-bis(4-piperidyl)propane molecule have been recorded between 4000–400 cm−1 region and 3500–150 cm−1 region, respectively. The vibrational frequencies of the molecule are investigated. The molecular geometry and vibrational frequencies of 1,3-bis(4-piperidyl...detailed

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