16917-42-3

Basic information

• Product Name: Benzaldehyde, 4-bromo-, phenylhydrazone
• CAS NO: 16917-42-3
• Molecular Formula: C13H11BrN2
• Molecular Weight: 275.148
• Mol File: 16917-42-3.mol
• Article Data: 30

Chemical Properties

• CAS DataBase Reference: Benzaldehyde, 4-bromo-, phenylhydrazone(CAS DataBase Reference)
• NIST Chemistry Reference: Benzaldehyde, 4-bromo-, phenylhydrazone(16917-42-3)
• EPA Substance Registry System: Benzaldehyde, 4-bromo-, phenylhydrazone(16917-42-3)

Safety Data

• Hazardous Substances Data: 16917-42-3(Hazardous Substances Data)

Upstream product

• 1122-91-4 4-bromo-benzaldehyde 
• 100-63-0 phenylhydrazine 
• 2826-24-6 4-bromobenzylidenemalononitrile 
• 62-53-3 aniline 
• 59-88-1 phenylhydrazine hydrochloride 
• 5877-51-0 N-(4-bromobenzylidene)aniline 
• 108-98-5 thiophenol 

Downstream Products

• 1122-91-4 4-bromo-benzaldehyde 
• 1200448-82-3 3-(4-bromophenyl)-1,6-diphenyl-4-tosyl-1,4,5,6-tetrahydro-1,2,4-triazine 
• 1223079-66-0 4-ethyl(carbethoxy)amino-5-(4-bromophenyl)-2-phenyl-2H-1,2,4-triazol-3(4H)-one 
• 955355-42-7 1-benzyl-2-(4-bromophenyl)-1H-benzo[d]imidazole 
• 380313-95-1 2-(4-bromobenzylidene)-1-benzyl-1-phenylhydrazine 
• 1251004-67-7 (3aR,6aR,3a'S,6a'S)-5,5'-[methylenebis(4,1-phenylene)]bis[3-(4-bromophenyl)-3a,6a-dihydro-1-phenylpyrrolo[3,4-c]pyrazole-4,6(1H,5H)-dione] 
• 1251004-96-2 (3aR,6aR,3a'S,6a'S)-5,5'-[oxybis(4,1-phenylene)]bis[3-(4-bromophenyl)-3a,6a-dihydro-1-phenylpyrrolo[3,4-c]pyrazole-4,6(1H,5H)-dione] 
• 1251005-13-6 (3aR,6aR,3a'S,6a'S)-5,5'-(1,4-phenylene)bis[3-(4-bromophenyl)-3a,6a-dihydro-1-phenylpyrrolo[3,4-c]pyrazole-4,6(1H,5H)-dione] 

Relevant articles and documents

Blatter-Radical-Grafted Mesoporous Silica as Prospective Nanoplatform for Spin Manipulation at Ambient Conditions

Quantum computing and quantum information processing (QC/QIP) crucially depend on the availability of suitable quantum bits (qubits) and methods of their manipulation. Most qubit candidates known to date are not applicable at ambient conditions. Herein, we propose radical-grafted mesoporous silica as a versatile and prospective nanoplatform for spin-based QC/QIP. Extremely stable Blatter-type organic radicals are used, whose electron spin decoherence time is profoundly long even at room temperature (up to Tm≈2.3 μs), thus allowing efficient spin manipulation by microwave pulses. The mesoporous structure of such composites is nuclear-spin free and provides additional opportunities of embedding guest molecules into the channels. Robustness and tunability of these materials promotes them as highly promising nanoplatforms for future QC/QIP developments.

Synthesis of and characterization of some Heterocyclic Compounds derived from Thiophenol

This research work involved preparation of heterogeneous pent lateral cyclic compounds (thiazolidine -4- one, benzothiazole, triazole, 4-oxothiazolidin) using thiophenol as raw materials: Thiophenol was reacted with mono chloroacetic acid in the presence of potassium hydroxide to prepare (sh1) followed by ortho amino aniline results the (sh2). The reaction of thiophenol with ethylchloroacetate afforded (sh3) and the reaction of (sh3) with thiosemicarbazide and 4% NaOH leads to ring closure giving 1,2,4- triazole (sh5). A treatment of thiophenol with hydrazine hydrate to obtain the intermediate (sh6) with aromatic aldehyde synthesized azomethines (sh7- sh9) then treated with mercaptoacetic acid to obtained (sh10-sh12). A treatment of thiophenol with chloroacetyl chloride produced (sh13) compound then treated with hydrazine hydrate to obtain (sh14) compound followed by bromobenzaldehyde synthesized azomethine (sh15) compound then treated with mercaptoacetic acid to obtained (sh16) compound. Characterization results for the prepared compounds using IR spectroscopy, NMR and melting points confirmed their chemical structures.

Identification of novel 1,3-diaryl-1,2,4-triazole-capped histone deacetylase 6 inhibitors with potential anti-gastric cancer activity

Histone deacetylase 6 (HDAC6) has emerged as a critical regulator of many cellular pathways in tumors due to its unique structure basis and abundant substrate types. Over the past few decades, the role played by HDAC6 inhibitors as anticancer agents has sparked great interest of biochemists worldwide. However, they were less reported for gastric cancer therapy. In this paper, with the help of bioisosteric replacement, in-house library screening, and lead optimization strategies, we designed, synthesized and verified a series of 1,3-diaryl-1,2,4-triazole-capped HDAC6 inhibitors with promising anti-gastric cancer activities. Amongst, compound 9r displayed the best inhibitory activity towards HDAC6 (IC50 = 30.6 nM), with 128-fold selectivity over HDAC1. Further BLI and CETSA assay proved the high affinity of 9r to HDAC6. In addition, 9r could dose-dependently upregulate the levels of acetylated α-tubulin, without significant effect on acetylated histone H3 in MGC803 cells. Besides, 9r exhibited potent antiproliferative effect on MGC803 cells, and promoted apoptosis and suppressed the metastasis without obvious toxicity, suggesting 9r would serve as a potential lead compound for the development of novel therapeutic agents of gastric cancer.