169448-87-7 Usage
Description
(R)-1-N-Boc-2-(hydroxymethyl)piperazine, also known as (R)-tert-Butyl 2-(hydroxymethyl)piperazine-1-carboxylate, is an organic compound with a unique molecular structure that features a piperazine ring and a hydroxymethyl group. It is characterized by its chiral center, which gives it the (R)-configuration. (R)-1-N-Boc-2-(hydroxymethyl)piperazine is a valuable building block in the synthesis of various pharmaceuticals and bioactive molecules due to its versatile reactivity and structural features.
Uses
Used in Pharmaceutical Industry:
(R)-1-N-Boc-2-(hydroxymethyl)piperazine is used as a key intermediate in the synthesis of novel substituted quinoline-8-carbonitrile derivatives. These derivatives possess androgen receptor degradation activity, which makes them potential candidates for the development of new drugs targeting androgen receptor-related diseases, such as prostate cancer and other androgen-dependent conditions.
In the field of medicinal chemistry, (R)-1-N-Boc-2-(hydroxymethyl)piperazine serves as a versatile starting material for the creation of new therapeutic agents. Its unique structure allows for further functionalization and modification, enabling the development of molecules with improved pharmacological properties, such as enhanced potency, selectivity, and bioavailability.
Additionally, (R)-1-N-Boc-2-(hydroxymethyl)piperazine may find applications in other industries, such as agrochemicals or materials science, where its specific structural features and reactivity can be exploited for the development of new products with desired properties. However, the primary focus of its use remains in the pharmaceutical industry, where its potential for contributing to the development of innovative therapeutics is most significant.
Check Digit Verification of cas no
The CAS Registry Mumber 169448-87-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,9,4,4 and 8 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 169448-87:
(8*1)+(7*6)+(6*9)+(5*4)+(4*4)+(3*8)+(2*8)+(1*7)=187
187 % 10 = 7
So 169448-87-7 is a valid CAS Registry Number.
InChI:InChI=1/C10H20N2O3/c1-10(2,3)15-9(14)12-5-4-11-6-8(12)7-13/h8,11,13H,4-7H2,1-3H3/t8-/m1/s1
169448-87-7Relevant articles and documents
Fluorine-substituted monocarbazole derivative as well as preparation method and application thereof (by machine translation)
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, (2020/06/20)
The invention belongs to the field of pharmaceutical chemistry, and relates to a fluorine-substituted monocarbazole derivative which is one or more of compounds represented by formula (I) and formula (II) or a pharmaceutically acceptable soluble salt formed by a compound represented by formula (II). The fluorine-substituted monocarbazole derivatives obtained in the application can be used for preparing DNA methyltransferase inhibitors or histone demethylase inhibitors. The fluorine-substituted monocarbazole derivative has an inhibitory effect on the proliferation of cancer cells and can be used for preparing medicaments for treating and/or preventing cancer. An in-vitro cancer cell proliferation inhibition test shows that the fluorine-substituted monocarbazole compound obtained by the invention shows anti-proliferation activity against human lung cancer cells (A549), human colon cancer cells (HCTCTCT116), human gastric cancer cells (MNK NK NK-45), human liver cancer cells (HepepepG2), RPMI PMI PMI PMI PMI PMI and Karpppp289. (by machine translation)
PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF
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Paragraph 0681; 0679, (2018/05/24)
The present invention provides compounds, compositions thereof, and methods of using the same.
