16949-90-9Relevant articles and documents
CIS-OXOPLATIN FOR TREATING STOMACH CANCER
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Page/Page column 24-25, (2020/01/24)
The invention relates to a pharmaceutical composition comprising cis-oxoplatin, or a salt and/or derivative thereof, for use as a medicament in the treatment and/or preventation of stomach cancer. The invention further relates to the pharmaceutical composition as described for use in the treatment of stomach cancer, wherein the cis-oxoplatin or derivative thereof is administered in a form that is transformed under acidic pH to a tetrachloro-oxoplatin (IV).
Halogenated PtIV Complexes from N-Halosuccinimide Oxidation of PtII Antitumor Drugs: Synthesis, Mechanistic Investigation, and Cytotoxicity
Xu, Zoufeng,Li, Cai,Tong, Zixuan,Ma, Lili,Tse, Man-Kit,Zhu, Guangyu
, p. 1706 - 1712 (2017/04/03)
Compared with square-planar PtII drugs, PtIV-based anticancer prodrugs are relatively inert under physiological conditions and can be activated after entering cells. The two axial ligands in PtIV complexes provide an opportunity to further functionalize these prodrugs. In recent years, much effort has been devoted to developing new PtIV-based anticancer prodrugs with higher cytotoxicity but fewer side effects. New synthetic methods, however, are intensely desired for structurally diversified and biologically distinct PtIV complexes. Herein, we utilize N-halosuccinimides as oxidants and carry out the oxidation reaction on PtII drugs including cisplatin, carboplatin, and oxaliplatin to obtain halogenated PtIV complexes. The related mechanism of the reaction of N-bromosuccinimide (NBS) with cisplatin in ethanol is thoroughly investigated. N-chlorosuccinimide is also utilized to obtain the respective dichlorinated PtIV complexes. When N-iodosuccinimide reacts with PtII drugs, new PtIV compounds containing iodide and succinimide ligands in the axial position are formed. Cytotoxicity test shows that some of the complexes are active against cisplatin-resistant human ovarian cancer cells. Our study provides a detailed understanding of the reaction mechanism between NBS and cisplatin and offers a more convenient strategy to obtain dichlorinated and new iodinated PtIV anticancer prodrugs.
Synthesis of pyrophosphatotetraamminediplatinum(II) complex and its transformations in hydrochloric acid solutions
Starkov,Patrushev
, p. 312 - 312 (2008/10/09)
A new method for the synthesis of [Pt2(NH3) 4P2O7] is proposed. Its transformations in a hydrochloric acid medium are described. Nauka/Interperiodica 2007.