169548-94-1

Basic information

• Product Name: ETHYL 1-(4-CHLOROPHENYL)-5-METHYL-1H-PYRAZOLE-4-CARBOXYLATE
• Synonyms: SALOR-INT L317527-1EA;ETHYL 1-(4-CHLOROPHENYL)-5-METHYL-1H-PYRAZOLE-4-CARBOXYLATE
• CAS NO: 169548-94-1
• Molecular Formula: C₁₃H₁₃ClN₂O₂
• Molecular Weight: 264.71
• Mol File: 169548-94-1.mol
• Article Data: 5

Chemical Properties

• Melting Point: 56 °C
• Boiling Point: 362.7±32.0 °C(Predicted)
• Appearance: /
• Density: 1.25±0.1 g/cm3(Predicted)
• PKA: -1.87±0.10(Predicted)
• CAS DataBase Reference: ETHYL 1-(4-CHLOROPHENYL)-5-METHYL-1H-PYRAZOLE-4-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 1-(4-CHLOROPHENYL)-5-METHYL-1H-PYRAZOLE-4-CARBOXYLATE(169548-94-1)
• EPA Substance Registry System: ETHYL 1-(4-CHLOROPHENYL)-5-METHYL-1H-PYRAZOLE-4-CARBOXYLATE(169548-94-1)

Safety Data

• Hazardous Substances Data: 169548-94-1(Hazardous Substances Data)

Upstream product

• 1073-69-4 N-4-chlorophenylhydrazine 
• 3788-94-1 2-ethoxymethylene-3-oxobutanoic acid ethyl ester 
• 134653-70-6 ethyl 2-[(dimethylamino)methylene]-3-oxobutanoate 
• 1073-70-7 4-chlorophenylhydrazine hydrochloride 
• 141-97-9 ethyl acetoacetate 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 

Downstream Products

• 187998-35-2 1-(4-chlorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid 
• 508180-93-6 1-(4-chlorophenyl)-5-methyl-1H-pyrazole-4-carbaldehyde 
• 288252-38-0 1-(4-chloro-phenyl)-5-methyl-1H-pyrazole-4-carbonyl chloride 
• 288250-37-3 1-(4-chlorophenyl)-N-[3-cyano-(4-piperazin-1-yl)phenyl]-5-methylpyrazole-4-carboxamide 
• 288250-47-5 1-(4-chlorophenyl)-N-[3-cyano-4-(4-morpholinopiperidin-1-yl)phenyl]-5-methylpyrazole-4-carboxamide 
• 288251-44-5 1-(4-chlorophenyl)-N-[3-cyano-4-(3-hydroxypropylthio)phenyl]-5-methylpyrazole-4-carboxamide 
• 288250-73-7 1-(4-chlorophenyl)-N-(3-cyano-4-pyrrolidinophenyl)-5-methylpyrazole-4-carboxamide 
• 288250-35-1 1-(4-chlorophenyl)-N-(3-cyano-4-piperidinophenyl)-5-methylpyrazole-4-carboxamide 
• 288250-40-8 1-(4-chlorophenyl)-N-[3-cyano-4-(hydroxypiperidin-1-yl)phenyl]-5-methylpyrazole-4-carboxamide 
• 288250-55-5 1-(4-chlorophenyl)-N-[3-cyano-4-(4-oxopiperidin-1-yl)phenyl]-5-methylpyrazole-4-carboxamide 
• 288250-75-9 1-(4-chlorophenyl)-N-(3-cyano-4-homopiperidinophenyl)-5-methylpyrazole-4-carboxamide 

Relevant articles and documents

Catalyst-free one-pot synthesis of 1,4,5-trisubstituted pyrazoles in 2,2,2-trifluoroethanol

A simple, efficient and three component one-pot synthesis of 1,4,5-trisubstituted pyrazoles by condensation of β-dicarbonyls, N,N-dimethylformamide dimethyl acetal (DMFDMA) and hydrazine derivatives in 2,2,2-trifluoroethanol without using any catalyst and activation, is described.

Pyrazole-amides and sulfonamides as sodium channel modulators

Compounds of the present invention modulate PN3 in mammals and are useful in treating pain in mammals.

Reaction of ethyl ethoxymethyleneacetoacetate with hydrazine monoderivatives

The reaction of ethyl α-ethoxymethyleneacetoacetate with acylhydrazines affords the corresponding acylhydrazones of α-formylacetoacetic ester. The 1H NMR and IR spectra revealed that the compounds obtained existed in ketoenamine (ketoenhydrazine) form. The condensation of 4-chlorophenyl-, 4-nitrophenyl-, 6-chloropyridazinyl-and 4-phenylphthalazinylhydrazines with the ethyl ethoxymethyleneacetoacetate is accompanied by cyclization into the corresponding 5-methyl-4-ethoxycarbonylpyrazoles.