169759-79-9

Basic information

• Product Name: METHYL 3-AMINO-5-(THIEN-2-YL)THIOPHENE-2-CARBOXYLATE
• Synonyms: Methyl3-amino-5-(thien-2-yl)thiophene-2-carboxylate97%
• CAS NO: 169759-79-9
• Molecular Formula: C₁₀H₉NO₂S₂
• Molecular Weight: 239.3167
• Mol File: 169759-79-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 444.7 °C at 760 mmHg
• Flash Point: 222.7 °C
• Appearance: /
• Density: 1.376 g/cm³
• Storage Temp.: 2-8°C
• PKA: 1.62±0.10(Predicted)
• CAS DataBase Reference: METHYL 3-AMINO-5-(THIEN-2-YL)THIOPHENE-2-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 3-AMINO-5-(THIEN-2-YL)THIOPHENE-2-CARBOXYLATE(169759-79-9)
• EPA Substance Registry System: METHYL 3-AMINO-5-(THIEN-2-YL)THIOPHENE-2-CARBOXYLATE(169759-79-9)

Safety Data

• Hazardous Substances Data: 169759-79-9(Hazardous Substances Data)

Usage

General Description

Methyl 3-amino-5-(thien-2-yl)thiophene-2-carboxylate is a chemical compound with the molecular formula C10H9NO2S2. It is a thiophene derivative that contains an amino group and a carboxylate ester group. The compound is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals, and has potential applications in the field of organic chemistry. Its thienyl group and carboxylate ester functionality make it a versatile and valuable intermediate in the production of various organic compounds. The compound's unique structure and reactivity make it a valuable tool for chemical research and development.

Upstream product

• 909301-63-9 (Z)-3-Chloro-3-thiophen-2-yl-acrylonitrile 
• 2365-48-2 Methyl thioglycolate 
• 88-15-3 2-Acetylthiophene 

Relevant articles and documents

Design, Synthesis, and Biological Evaluation of 6-Substituted Thieno[3,2- d]pyrimidine Analogues as Dual Epidermal Growth Factor Receptor Kinase and Microtubule Inhibitors

The clinical evidence for the success of tyrosine kinase inhibitors in combination with microtubule-targeting agents prompted us to design and develop single agents that possess both epidermal growth factor receptor (EGFR) kinase and tubulin polymerization inhibitory properties. A series of 6-aryl/heteroaryl-4-(3′,4′,5′-trimethoxyanilino)thieno[3,2-d]pyrimidine derivatives were discovered as novel dual tubulin polymerization and EGFR kinase inhibitors. The 4-(3′,4′,5′-trimethoxyanilino)-6-(p-tolyl)thieno[3,2-d]pyrimidine derivative 6g was the most potent compound of the series as an antiproliferative agent, with half-maximal inhibitory concentration (IC50) values in the single- or double-digit nanomolar range. Compound 6g bound to tubulin in the colchicine site and inhibited tubulin assembly with an IC50 value of 0.71 μM, and 6g inhibited EGFR activity with an IC50 value of 30 nM. Our data suggested that the excellent in vitro and in vivo profile of 6g may be derived from its dual inhibition of tubulin polymerization and EGFR kinase.

The discovery and optimization of pyrimidinone-containing MCH R1 antagonists

Optimization of a series of constrained melanin-concentrating hormone receptor 1 (MCH R1) antagonists has provided compounds with potent and selective MCH R1 activity. Details of the optimization process are provided and the use of one of the compounds in