169957-63-5Relevant articles and documents
Dicationic 2-fluorenonylcarbapenems: Potent anti-MRS agents with improved solubility and pharmacokinetic properties
Greenlee, Mark L.,Laub, Joanne B.,Rouen, Gregory P.,DiNinno, Frank,Hammond, Milton L.,Huber, Joann L.,Sundelof, Jon G.,Hammond, Gail G.
, p. 3225 - 3230 (2007/10/03)
The synthesis and biological evaluation of a series of dicationic-substituted 2-fluorenonylcarbapenems is described. This class of compounds showed enhanced water solubility while maintaining potent activity against MRS. Introduction of a 1-β-methyl substituent was found to improve pharmacokinetics.