170230-17-8

Basic information

• Product Name: Benzenamine, 4-chloro-3-[2-(dimethylamino)ethoxy]-
• CAS NO: 170230-17-8
• Molecular Formula: C10H15ClN2O
• Molecular Weight: 214.695
• Mol File: 170230-17-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Benzenamine, 4-chloro-3-[2-(dimethylamino)ethoxy]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenamine, 4-chloro-3-[2-(dimethylamino)ethoxy]-(170230-17-8)
• EPA Substance Registry System: Benzenamine, 4-chloro-3-[2-(dimethylamino)ethoxy]-(170230-17-8)

Safety Data

• Hazardous Substances Data: 170230-17-8(Hazardous Substances Data)

Upstream product

• 345893-27-8 tert-butyl (4-chloro-3-hydroxyphenyl)carbamate 
• 30533-51-8 dimethylaminoethyl chloride (hydrochloride) 
• 1349821-33-5 N-[4-chloro-3-(2-dimethylaminoethoxy)phenyl]acetamide 
• 28443-52-9 2-chloro-5-acetylamino phenol 
• 619-10-3 5-nitro-2-chlorophenol 

Downstream Products

• 345892-67-3 N-[4-Chloro-3-(2-dimethylamino-ethoxy)-phenyl]-3,4-dimethoxy-benzenesulfonamide 
• 345892-68-4 4,5-Dibromo-N-[4-chloro-3-(2-dimethylamino-ethoxy)-phenyl]-2-thiophenesulfonamide 
• 345892-69-5 3,4-Dibromo-N-[4-chloro-3-(2-dimethylamino-ethoxy)-phenyl]-benzenesulfonamide 
• 345892-71-9 SB 611812 
• 345892-72-0 2-Bromo-N-[4-chloro-3-(2-dimethylamino-ethoxy)-phenyl]-4,5-dimethoxy-benzenesulfonamide 
• 758711-95-4 1-(4-Chloro-3-(2-dimethylamino-ethoxy)-phenyl)-3-(2-methyl-quinolin-4-yl)-urea 
• 1428555-04-7 C₁₈H₂₀ClF₃N₂O 
• 1428555-02-5 C₁₇H₂₀BrClN₂O 
• 1428555-01-4 C₁₇H₂₁ClN₂O 

Relevant articles and documents

POTENT AND SELCTIVE COMPOUNDS AS SEROTONIN 1B RECEPTOR MODULATORS

The present invention relates to new compounds of formula (I): as modulators of serotonin receptor 1B (5-HTR1B) also known as 5-hydroxytryptamine receptor 1B (5-HT1B). The compounds are of potential utility in the treatment of diseases and conditions mediated by serotonin receptor type 1B (5-HTR1B), such as cancer, including blood cancer and solid tumors, respiratory diseases and hepatic disorders.

Synthesis, antimalarial activity, and structure-activity relationship of 7-(2-Phenoxyethoxy)-4(1H)-quinolones

ICI 56,780 (5) displayed causal prophylactic and blood schizonticidal activity (ED50 = 0.05 mg/kg) in rodent malaria models but produced rapid acquisition of parasitological resistance in P. berghei infected mice. Herein we describe the synthesis of analogues of 5 with EC50 as low as 0.15 nM against multidrug resistant P. falciparum. Optimal activity with low cross-resistance indexes (RI) to atovaquone was achieved by introducing ortho-substituted aryl moieties at the 3-position of the 7-(2-phenoxyethoxy)- 4(1H)-quinolone core. (Figure presented