170288-29-6

Basic information

• Product Name: N-(4-(methylthio)phenyl)formamide
• Synonyms: N-(4-(methylthio)phenyl)formamide
• CAS NO: 170288-29-6
• Molecular Weight: 167.232
• Mol File: 170288-29-6.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: N-(4-(methylthio)phenyl)formamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-(methylthio)phenyl)formamide(170288-29-6)
• EPA Substance Registry System: N-(4-(methylthio)phenyl)formamide(170288-29-6)

Safety Data

• Hazardous Substances Data: 170288-29-6(Hazardous Substances Data)

Upstream product

• 68-12-2 N,N-dimethyl-formamide 
• 104-96-1 4-methylsulfanylaniline 
• 701-57-5 1-methylthio-4-nitro-benzene 
• 124-38-9 carbon dioxide 
• 2258-42-6 formyl acetic anhydride 
• 1632-84-4 4-(methylthio)phenyl isocyanate 
• 2043-61-0 cyclohexanecarbaldehyde 
• 64-18-6 formic acid 
• 109-94-4 formic acid ethyl ester 
• 1783-81-9 3-methylmercaptoaniline 

Downstream Products

• 1110272-19-9 C₁₉H₁₆N₄S 
• 1110272-21-3 2-(4-pyridinyl)-N-(4-(methylthio)phenyl)imidazo[1,2-a]pyridin-3-amine 
• 1110272-29-1 2-(2-pyridinyl)-N-(4-(methylsulfonyl)phenyl)imidazo[1,2-a]pyridin-3-amine 
• 1110272-30-4 2-(4-pyridinyl)-N-(4-(methylsulfonyl)phenyl)imidazo[1,2-a]pyridin-3-amine 
• 165806-92-8 pyridine-4-carboxaldehyde (4-methylthiophenyl)imine 
• 945396-92-9 N-(4-chloropyrimidin-2-yl)-N-(3-methylsulfanylphenyl)formamide 
• 945396-41-8 N'-(6-chlorobenzofuran-7-yl)-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamine 
• 945396-91-8 4-chloro-N-(3-methylsulfanylphenyl)pyrimidin-2-amine 
• 945396-93-0 4-chloro-N-[3-(methylsulfonyl)phenyl]-2-pyrimidinamine 

Relevant articles and documents

HCl-mediated transamidation of unactivated formamides using aromatic amines in aqueous media

We report transamidation protocol to synthesize a range of secondary and tertiary amides from weakly nucleophilic aromatic and hetero-aryl amines with low reactive formamide derivatives, utilizing hydrochloric acid as catalyst. This current acid mediated strategy is beneficial because it eliminates the need for a metal catalyst, promoter or additives in the reaction, simplifies isolation and purification. Notably, this approach conventionally used to synthesize molecules on gram scales with excellent yields and a high tolerance for functional groups.

Direct: N -formylation of nitroarenes with CO2

Herein we describe a straightforward N-formylation of nitroarenes with CO2 to access N-aryl formamides exclusively in the presence of iron and hydrosilane as additives. This protocol showcases a good tolerance of a wide range of nitroarenes and nitroheteroarenes.

Radical perfluoroalkylation - Easy access to 2-perfluoroalkylindol-3-imines-via electron catalysis

Arylisonitriles (2 equivalents) react with alkyl and perfluoroalkyl radicals to form 2-alkylated indole-3-imines via two sequential additions to the isonitrile moiety followed by homolytic aromatic substitution. The three component reaction comprises three C-C bond formations. The endocyclic imine functionality in the products is more reactive in follow up chemistry and hydrolysis of the exocyclic imine leads to 3-oxindoles that show fluorescence properties.