17040-20-9Relevant articles and documents
SEROTONIN 5-HT2B INHIBITORY COMPOUNDS
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, (2020/10/18)
The compounds of the invention, as described herein, are novel serotonin 5-HT2B antagonists useful for the treatment of myxomatous mitral valve degeneration (MMVD), congestive heart failure (CHF), and/or asymptomatic heart failure in animals, preferably c
The synthesis of a [2.2]paracyclophane-derived secondary phosphine oxide and a study of its reactivity
Mungalpara, Maulik N.,Wang, Jingjing,Coles, Martyn P.,Plieger, Paul G.,Rowlands, Gareth J.
, p. 5519 - 5527 (2018/05/26)
A planar chiral secondary phosphine oxide based on [2.2]paracyclophane was synthesized and its chemistry investigated; it was shown to be a competent pre-ligand in palladium(0)-mediated reactions, and displayed promising activity in gold(I)-catalysed cyclisations. The secondary phosphine oxide could be transformed into a collection of P-stereogenic tertiary phosphine oxides. These are rare examples of the planar chirality of [2.2]paracyclophane being combined with a P-stereogenic centre. Unfortunately, epimerisation of the phosphorus stereocentre during reduction limits the use of this chemistry.
Bifunctional AKR1C3 inhibitors/androgen receptor modulators and methods of use thereof
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Page/Page column 58; 59; 61; 62, (2016/03/19)
The invention includes compositions comprising selective AKR1C3 inhibitors. The invention also includes compositions comprising bifunctional AKR1C3 inhibitors and selective androgen receptor modulators. The invention further includes methods of treatment using the compositions of the invention.