170456-80-1

Basic information

• Product Name: 1H-Indole, 3-iodo-1-[(4-methylphenyl)sulfonyl]-
• Synonyms: 3-iodo-1-tosylindole;3-iodo-1-[(4-methylbenzene)sulfonyl]-1H-indole;3-Iodo-1-(toluene-4-sulfonyl)-1H-indole;3-iodo-1-(4-toluenesulfonyl)indole;3-iodo-N-tosylindole;3-iodo-1-[(4-methylphenyl)sulphonyl]-1H-indole
• CAS NO: 170456-80-1
• Molecular Formula: C15H12INO2S
• Molecular Weight: 397.236
• Mol File: 170456-80-1.mol
• Article Data: 21

Chemical Properties

• CAS DataBase Reference: 1H-Indole, 3-iodo-1-[(4-methylphenyl)sulfonyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole, 3-iodo-1-[(4-methylphenyl)sulfonyl]-(170456-80-1)
• EPA Substance Registry System: 1H-Indole, 3-iodo-1-[(4-methylphenyl)sulfonyl]-(170456-80-1)

Safety Data

• Hazardous Substances Data: 170456-80-1(Hazardous Substances Data)

Usage

General Description

1H-Indole, 3-iodo-1-[(4-methylphenyl)sulfonyl]- is a chemical compound with the molecular formula C16H14INO2S. It is a derivative of indole, a heterocyclic compound that is commonly found in many natural products and pharmaceuticals. The compound is characterized by the presence of an iodine atom and a sulfonyl group attached to the indole ring. This chemical may have potential applications in organic synthesis, medicinal chemistry, and material science due to its unique structural features and reactivity. Its properties and uses may vary depending on the specific context and application.

Upstream product

• 771-50-6 1H-indole-3-carboxylic acid 
• 98-59-9 p-toluenesulfonyl chloride 
• 370090-66-7 1-tosyl-1H-indole-3-carboxylic acid 
• 26340-47-6 3-Iodo-1H-indole 
• 120-72-9 indole 
• 527686-25-5 4-methyl-N-(2-((trimethylsilyl)ethynyl)phenyl)benzenesulfonamide 
• 31271-90-6 1-(p-toluenesulfonyl)-1H-indole 
• 103529-16-4 2-[(trimethylsilyl)ethynyl]aniline 
• 615-43-0 2-iodophenylamine 

Downstream Products

• 1350542-00-5 (R)-tert-butyl 2,2-dimethyl-4-(2-(1-tosyl-1H-indol-3-yl)ethynyl)oxazolidine-3-carboxylate 
• 1350542-02-7 (R)-tert-butyl 2,2-dimethyl-4-(2-(1-tosyl-1H-indol-3-yl)ethyl)oxazolidine-3-carboxylate 
• 1350542-04-9 tert-butyl (R)-1-hydroxy-4-(1-tosyl-1H-indol-3-yl)butan-2-ylcarbamate 
• 1350542-07-2 tert-butyl (R)-1-(methoxycarbonyl)-3-(1-tosyl-1H-indol-3-yl)propylcarbamate 
• 1370022-76-6 (3-(2-methoxyphenyl)-1H-indol-1-yl)methanol 
• 1370022-78-8 (3-(2-bromophenyl)-1H-indol-1-yl)methanol 
• 56366-27-9 3-(2-methoxyphenyl)-1H-indole 
• 1504-16-1 3-phenyl-1H-indole 
• 1418308-56-1 C₃₅H₂₃BF₂N₂ 
• 1418307-55-7 C₂₂H₁₅NO₃S 
• 1418307-54-6 C₂₂H₁₅I₂NO₃S 
• 1452128-87-8 (E)-2-(6-methoxynaphthalin-2-yl)-3-phenylacrylaldehyde 
• 1452128-90-3 3-(3-phenyl-1H-pyrazol-4-yl)-1-tosyl-1H-indole 

Relevant articles and documents

Selectively substituted thiophenes and indoles by a tandem palladium-catalyzed multicomponent reaction

A variety of di- and trisubstituted thiophenes were synthesized by a one-pot palladium-catalyzed ortho-alkylation sequence terminated by either Heck or C-H coupling. Initial results toward the functionalization of indoles are also presented.

Cobalt-Catalyzed Hydroalkynylation of Vinylaziridines

Transition metal-catalyzed hydroalkynylation reactions are efficient transformations allowing the straightforward formation of functionalized alkynes. Therein, we disclose the cobalt-catalyzed hydroalkynylation of vinylaziridines giving rise to both linea

Disulfide-Catalyzed Iodination of Electron-Rich Aromatic Compounds

Herein, a disulfide-catalyzed electrophilic iodination of aromatic compounds using 1,3-diiodo-5,5-dimethylhydantoin (DIH) has been developed. The disulfide activates DIH as a Lewis base to promote the iodination reaction in acetonitrile under mild conditions. This system is applicable to a wide range of electron-rich aromatic compounds, including acetanilide, anisole, imidazole, and pyrazole derivatives.

Enantioselective Synthesis of Cyclohepta[ b]indoles via Pd-Catalyzed Cyclopropane C(sp3)-H Activation as a Key Step

An enantioselective synthesis of functionalized cyclohepta[b]indoles via Pd-catalyzed cyclopropane C-H activation followed by olefination and indole-vinylcyclopropane rearrangement is reported. The design of the chiral cyclopropane precursor was such that both enantiomeric cyclohepta[b]indoles were accessed from a single compound exhibiting a "hidden" symmetry plane. The scope of the method was demonstrated by varying the substituents on the cyclopropane as well as on the heterocycle itself.