1706-12-3

Basic information

• Product Name: 1-METHYL-4-PHENOXY-BENZENE
• Synonyms: 1-METHYL-4-PHENOXY-BENZENE;p-phenoxytoluene;4-Methyldiphenyl ether;4-Methylphenylphenyl ether;Phenyl 4-methylphenyl ether;Phenyl p-tolyl ether;Phenyl(4-methylphenyl) ether
• CAS NO: 1706-12-3
• Molecular Formula: C₁₃H₁₂O
• Molecular Weight: 184.23378
• EINECS: 216-944-3
• Mol File: 1706-12-3.mol
• Article Data: 164

Chemical Properties

• Melting Point: 104 °C
• Boiling Point: 268.8°Cat760mmHg
• Flash Point: 110.6°C
• Appearance: /
• Density: 1.045g/cm³
• Vapor Pressure: 0.0125mmHg at 25°C
• Refractive Index: 1.566
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-METHYL-4-PHENOXY-BENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-METHYL-4-PHENOXY-BENZENE(1706-12-3)
• EPA Substance Registry System: 1-METHYL-4-PHENOXY-BENZENE(1706-12-3)

Safety Data

• Hazardous Substances Data: 1706-12-3(Hazardous Substances Data)

Usage

General Description

1-METHYL-4-PHENOXY-BENZENE, also known as PMPOB, is a chemical compound with the molecular formula C13H12O. It is a colorless to light yellow liquid that is insoluble in water but soluble in organic solvents. PMPOB is primarily used as an intermediate in the synthesis of pharmaceuticals, dyes, and other organic compounds. It is also used in research and development as a building block for organic synthesis. The compound is known to have low acute toxicity and is not considered to be a significant environmental or health hazard when handled and used according to proper safety guidelines.

InChI:InChI=1/C13H12O/c1-11-7-9-13(10-8-11)14-12-5-3-2-4-6-12/h2-10H,1H3

Upstream product

• 108-86-1 bromobenzene 
• 106-44-5 p-cresol 
• 1192-96-7 potassium p-cresolate 
• 591-50-4 iodobenzene 
• 106-38-7 para-bromotoluene 
• 100-67-4 potassium phenolate 
• 20927-98-4 2-p-tolyloxy-aniline 
• 41295-20-9 4-(4-methylphenoxy)aniline 
• 108-95-2 phenol 
• 1121-70-6 sodium 4-methylphenoxide 
• 624-31-7 4-tolyl iodide 
• 139-02-6 sodium phenoxide 
• 56530-34-8 p-methyldiphenyliodonium chloride 
• 108-98-5 thiophenol 

Downstream Products

• 106-44-5 p-cresol 
• 36881-42-2 1-(bromomethyl)-4-phenoxybenzene 
• 6103-33-9 2-methylphenoxathiin 
• 2215-77-2 4-Phenoxybenzoic acid 
• 30427-93-1 1-bromo-4-(4-methylphenoxy)benzene 
• 2914-76-3 (4-methyl-2-nitro-phenyl)-(4-nitro-phenyl)-ether 
• 95523-77-6 4-p-tolyloxy-benzophenone 
• 71815-31-1 4-(p-tolyloxy)acetophenone 
• 88112-82-7 3-<4-(4-methylphenoxy)benzoyl>acrylic acid 
• 67-36-7 4-phenoxy benzaldehyde 
• 3096-81-9 4-phenoxybenzonitrile 
• 94402-59-2 4-(4-methylphenoxy)phenacyl chloride 
• 2215-90-9 4-Methoxymethyl-diphenylether 
• 74317-67-2 4-phenoxy-benzaldehyde-dimethylacetal 

Relevant articles and documents

Oxidation of m-Phenoxytoluene with Ceric Trifluoroacetate

Ceric trifluoroacetate in aqueous trifluoroacetic acid has been found to be especially effective for the oxidation of activated toluenes to the corresponding aldehydes.Ceric ion is consumed in stoichiometric amounts but can be regenerated electrochemically at high current efficiencies (95 percent).A detailed study of the oxidation of m-phenoxytoluene to m-phenoxybenzaldehyde is presented.A study of the reaction mechanism, which involves both cations and radical cations, led to a choise of cosolvents which stabilize these intermediates and thus increase the yield of aldehyde formation.

Ligand- and Counterion-Assisted Phenol O-Arylation with TMP-Iodonium(III) Acetates

High reactivity of trimethoxyphenyl (TMP)-iodonium(III) acetate for phenol O-arylation was achieved. It was first determined that the TMP ligand and acetate anion cooperatively enhance the electrophilic reactivity toward phenol oxygen atoms. The proposed method provides access to various diaryl ethers in significantly higher yields than the previously reported techniques. Various functional groups, including aliphatic alcohol, boronic ester, and sterically hindered groups, were tolerated during O-arylation, verifying the applicability of this ligand- and counterion-assisted strategy.

Magnetization of graphene oxide nanosheets using nickel magnetic nanoparticles as a novel support for the fabrication of copper as a practical, selective, and reusable nanocatalyst in C-C and C-O coupling reactions

Catalyst species are an important class of materials in chemistry, industry, medicine, and biotechnology. Moreover, waste recycling is an important process in green chemistry and is economically efficient. Herein, magnetic graphene oxide was synthesized using nickel magnetic nanoparticles and further applied as a novel support for the fabrication of a copper catalyst. The catalytic activity of supported copper on magnetic graphene oxide (Cu-ninhydrin@GO-Ni MNPs) was investigated as a selective, practical, and reusable nanocatalyst in the synthesis of diaryl ethers and biphenyls. Some of the obtained products were identified by NMR spectroscopy. This nanocatalyst has been characterized by atomic absorption spectroscopy (AAS), scanning electron microscopy (SEM), wavelength dispersive X-ray spectroscopy (WDX), energy-dispersive X-ray spectroscopy (EDS), X-ray diffraction (XRD), thermogravimetric analysis (TGA), Fourier transform infrared spectroscopy (FT-IR), and vibrating sample magnetometer (VSM) techniques. The results obtained from SEM shown that this catalyst has a nanosheet structure. Also, XRD and FT-IR analysis show that the structure of graphene oxide and nickel magnetic nanoparticles is stable during the modification of the nanoparticles and synthesis of the catalyst. The VSM curve of the catalyst shows that this catalyst can be recovered using an external magnet; therefore, it can be reused several times without a significant loss of its catalytic efficiency. The heterogeneity and stability of this nanocatalyst during organic reactions was confirmed by the hot filtration test and AAS technique.