1709825-83-1 Usage
Description
Beclomethasone-11,17,21-tripropionate is a synthetic glucocorticoid steroid that exhibits potent anti-inflammatory and immunosuppressive properties. It is a derivative of beclomethasone-17,21-dipropionate with an additional propionate group at the 11th position, enhancing its therapeutic efficacy. This medication is primarily used to manage various inflammatory conditions by reducing inflammation and swelling in the affected areas, thereby alleviating symptoms and improving the quality of life for patients.
Uses
Used in Respiratory Conditions:
Beclomethasone-11,17,21-tripropionate is used as an anti-inflammatory and immunosuppressive agent for the treatment of respiratory conditions such as asthma, allergic rhinitis, and chronic obstructive pulmonary disease (COPD). It works by reducing inflammation and swelling in the airways, making it easier for patients to breathe. The medication is typically administered via inhalation, allowing for targeted delivery to the respiratory system and minimizing systemic side effects.
Used in Dermatological Applications:
In the dermatological field, beclomethasone-11,17,21-tripropionate is used as a topical treatment for various skin conditions, including eczema, psoriasis, and dermatitis. It is formulated in creams and ointments, which provide localized relief by reducing inflammation, itching, and redness associated with these skin disorders. The use of a potent glucocorticoid like beclomethasone-11,17,21-tripropionate helps to control severe skin inflammation and promote healing.
Used in Ophthalmic Applications:
Beclomethasone-11,17,21-tripropionate is also used in ophthalmology as an anti-inflammatory agent for the treatment of eye conditions such as uveitis, iritis, and allergic conjunctivitis. It is available in the form of eye drops or ointments, which help to reduce inflammation, swelling, and redness in the affected eye, providing relief and improving visual comfort.
Used in Gastroenterology:
In the field of gastroenterology, beclomethasone-11,17,21-tripropionate may be used for the treatment of inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis. It can help to reduce inflammation in the gastrointestinal tract, alleviating symptoms and promoting healing of the affected tissues.
Overall, beclomethasone-11,17,21-tripropionate is a versatile medication with a wide range of applications in various medical fields. Its potent anti-inflammatory and immunosuppressive effects make it an effective treatment option for a variety of inflammatory conditions, improving the quality of life for patients and helping to manage their symptoms effectively. However, it is crucial to use this medication under the guidance of a healthcare professional to minimize the risk of side effects and ensure optimal therapeutic outcomes.
Check Digit Verification of cas no
The CAS Registry Mumber 1709825-83-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,7,0,9,8,2 and 5 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1709825-83:
(9*1)+(8*7)+(7*0)+(6*9)+(5*8)+(4*2)+(3*5)+(2*8)+(1*3)=201
201 % 10 = 1
So 1709825-83-1 is a valid CAS Registry Number.
1709825-83-1Relevant articles and documents
Practical and scalable synthesis of beclomethasone dipropionate
Welideniya, Dhanushi T.,Jayathilaka, Adeesha S.,Acharige, Anjana Delpe,Samanthi,Wanninayake, Umayangani K.,Perera, Shashika S.,Rajapaksha, Weranga,Fernando, Chamod C.,Hewadikaram, Madhavi,Buddhika, Janani,Gunasekara, Pivini,Karunaratne, Veranja,Amaratunga,Gunasekera, Dinara S.
, (2021/12/22)
Beclomethasone dipropionate (1) is a synthetic corticosteroid with anti-inflammatory, antipruritic, and anti-allergy properties. It is widely used to treat asthma, allergic rhinitis, and dermatoses. However, existing synthetic routes to this active pharmaceutical ingredient (API) contain steps resulting in low and/or inconsistent yields, and use obsolete reagents. Such inconsistencies coupled with a lack of reliable experimental data makes laboratory-scale and large-scale synthesis of this API difficult and time-consuming. In this paper, we report a practical and scalable approach to synthesize 1 from the readily available steroidal intermediate, 16β-methyl epoxide (3, DB-11). A gram-scale to kilogram-scale synthesis of 1 was achieved with 82% yield, using a cost-effective and scalable methodology. Selective propionylation of the hydroxyl groups at C17 and C21 demonstrate the fact that this approach can be conveniently implemented in fine chemical industries.
A dipropionate double-c ester synthesis method free of organic solvents
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Paragraph 0032, (2018/09/26)
The invention relates to a synthetic method of a beclomethasone dipropionate organic-free solvent. According to the method, beclomethasone 11, 17, 21-tripropionate is taken as the raw material and reacts in an organic solvent with a gluconic acid solution or an aqueous solution of ester capable of being converted into gluconic acid in water to prepare the beclomethasone dipropionate organic-free solvent.
