17103-52-5

Basic information

• Product Name: SulfaMethoxazole Related CoMpound F
• Synonyms: SulfaMethoxazole Related CoMpound F;4-Amino-N-(3-methyl-5-isoxazolyl)benzenesulfonamide;Sulfamethoxazole EP Impurity F;Sulfamethoxazole impurity F (EP)
• CAS NO: 17103-52-5
• Molecular Formula: C₁₀H₁₁N₃O₃S
• Molecular Weight: 253.27764
• EINECS: 604-604-1
• Mol File: 17103-52-5.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: SulfaMethoxazole Related CoMpound F(CAS DataBase Reference)
• NIST Chemistry Reference: SulfaMethoxazole Related CoMpound F(17103-52-5)
• EPA Substance Registry System: SulfaMethoxazole Related CoMpound F(17103-52-5)

Safety Data

• Hazardous Substances Data: 17103-52-5(Hazardous Substances Data)

Usage

Description

SulfaMethoxazole Related CoMpound F, also known as Isosulfamethoxazole, is an impurity found in the antibacterial drug Sulfamethoxazole (S699086). It is a sulfonamide antibiotic that functions by inhibiting the enzyme dihydropteroate synthase, which in turn blocks the synthesis of dihydrofolic acid.

Uses

There are no specific applications mentioned for SulfaMethoxazole Related CoMpound F in the provided materials. However, it is important to note that it is an impurity in the antibacterial drug Sulfamethoxazole, which is used for treating bacterial infections.

Upstream product

• 14678-02-5 5-amino-3-methylisoxazole 
• 121-60-8 p-acetylaminobenzenesulfonyl chloride 
• 24939-24-0 4-aminobenzenesulfonyl chloride 
• 88614-99-7 N-(4-(N-(3-methylisoxazol-5-yl)sulfamoyl)phenyl)acetamide 

Downstream Products

• 910622-65-0 4-(2-amino-3-cyano-4-phenyl-pyrrol-1-yl)-N-(3-methyl-isoxazol-5-yl)-benzenesulfonamide 
• 1148108-95-5 N-(5-methylisoxazol-3-yl)-4-(3-(4-(N-(1-phenyl-1H-pyrazol-5-yl)-sulfamoyl)phenyl)thioureido)benzenesulfonamide 
• 1224288-68-9 ethyl 2-cyano-3-{4-[N-(3-methylisoxazol-5-yl)sulfamoyl]phenylamino}acrylate 
• 1224288-66-7 4-(2,2-dicyanovinylamino)-N-(3-methylisoxazol-5-yl)benzenesulfonamide 
• 1449376-69-5 C₂₀H₁₆ClN₅O₃S₂ 
• 1449365-35-8 C₁₉H₁₅ClN₄O₃S 
• 1489236-21-6 N-(3-methylisoxazol-5-yl)-4-(7-(trifluoromethyl)quinolin-4-ylamino)benzenesulfonamide 
• 1491007-10-3 (E)-N-(4-(N-(3-methylisoxazol-5-yl)sulfamoyl)phenyl)-N'-(7-(trifluoromethyl)quinolin-4-yl)carbamimidothioic acid 

Relevant articles and documents

Facile and convenient synthesis of new isoxazolo[5,4b]pyridine, pyrrolo[3,2-d]isoxazole, isoxazolo[5,4-b]azepine-4,7-dione and isoxazole derivatives with potential anticancer activity

The readily available 3-methylisoxazol-5-amine (1) has been used as a key intermediate for the synthesis of isoxazolo[5,4-b]pyridine, pyrrolo[3,2-d]isoxazole, isoxazolo[5,4-b]azepine-4,7-dione and isoxazole derivatives via its reactions with some chemical reagents. Sixteen compounds were designed to study their cytotoxic properties against three human cell lines: colorectal carcinoma (HCT-116), prostate cancer (PC3) and normal lung fibroblast (WI-38), using the MTT colorimetric assay. 5-Fluorouracil, a well-known anticancer drug, was used for comparison. Among the tested candidates, pyrrolo[3,2-d]isoxazole 5 and isoxazole derivatives 11-14 showed the highest activity against the tested cancer cell lines with good selectivity by their lower toxicity against normal cells.