171075-74-4Relevant articles and documents
Diverse synthesis of the C ring fragment of bryostatins via Zn/Cu-promoted conjugate addition of α-hydroxy iodide with enone
Chu, Zhiwen,Tong, Ruiqi,Yang, Yufan,Song, Xuanyi,Hu, Tian bao,Fan, Yu,Zhao, Chen,Gao, Lu,Song, Zhenlei
supporting information, p. 1 - 4 (2020/12/21)
A convergent approach to 1,5-hydroxy ketones, the general precursors for constructing the C ring of bryostatins, has been developed via a Zn/Cu-promoted conjugate addition of α-hydroxy iodides with enones. The reaction leads to direct formation of the C21-C22 bond and tolerates diverse functionalities at the C17-, C18- and C24-positions. The approach also enables a more concise synthesis of the known C ring intermediate (10 longest linear steps and 14 total steps), in contrast to its previous synthesis (17 longest linear steps and 22 total steps) in our total synthesis of bryostatin 8.
Heteroaryl-Substituted Hexahydropyrano[3,4-d][1,3]Thiazin-2-Amine Compounds
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Paragraph 0178; 0179, (2014/08/19)
The present invention is directed to compounds, tautomers and pharmaceutically acceptable salts of the compounds which are disclosed, wherein the compounds have the structure of Formula I, and the variables R1 and R2 are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
A Concise Enantioselective Synthesis of (+)-Muscarine from (R)-O-Benzylglycidol
Takano, Seiichi,Iwabuchi, Yoshiharu,Ogasawara, Kunio
, p. 1371 - 1372 (2007/10/02)
A concise enantioselective synthesis of (+)-muscarine has been established via the novel formation of a 3,4-dihydrofuran starting from (R)-O-benzylglycidol.
