171178-21-5

Basic information

• Product Name: 6-CHLORO-3-NITROPYRIDINE-2-CARBOXAMIDE
• Synonyms: 6-CHLORO-3-NITROPYRIDINE-2-CARBOXAMIDE;2-CARBOXAMIDE-6-CHLORO-3-NITROPYRIDINE;6-chloro-3-nitro-2-PyridinecarboxaMide;6-Chloro-3-nitro-pyridine-2-carboxylic acid amide
• CAS NO: 171178-21-5
• Molecular Formula: C₆H₄ClN₃O₃
• Molecular Weight: 201.57
• Mol File: 171178-21-5.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 323.607°C at 760 mmHg
• Flash Point: 149.512°C
• Appearance: /
• Density: 1.611g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.633
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 13.58±0.50(Predicted)
• CAS DataBase Reference: 6-CHLORO-3-NITROPYRIDINE-2-CARBOXAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-CHLORO-3-NITROPYRIDINE-2-CARBOXAMIDE(171178-21-5)
• EPA Substance Registry System: 6-CHLORO-3-NITROPYRIDINE-2-CARBOXAMIDE(171178-21-5)

Safety Data

• Hazardous Substances Data: 171178-21-5(Hazardous Substances Data)

Usage

General Description

6-Chloro-3-nitropyridine-2-carboxamide is a chemical compound with the molecular formula C6H4ClN3O3. It is a yellow crystalline solid that is used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 6-CHLORO-3-NITROPYRIDINE-2-CARBOXAMIDE is a member of the pyridine family, which is known for its diverse biological activities. It can be used as a building block in the synthesis of various heterocyclic compounds and has applications in the pharmaceutical and agricultural industries. Additionally, it has potential as a research tool in the study of pyridine derivatives and their biological properties. Overall, 6-Chloro-3-nitropyridine-2-carboxamide is a versatile chemical with a range of potential uses in various fields of science and industry.

InChI:InChI=1/C6H4ClN3O3/c7-4-2-1-3(10(12)13)5(9-4)6(8)11/h1-2H,(H2,8,11)

Upstream product

• 93683-65-9 6-chloro-3-nitropicolinonitrile 
• 16013-85-7 2,6-dicholoro-3-nitropyridine 

Downstream Products

• 175358-01-7 3-amino-6-chloro-pyridine-2-carboxylic acid amide 
• 267243-45-8 6-amino-3-nitropyridine-2-carboxamide 
• 882856-82-8 tert-butyl [(3R,4R)-1-[6-(aminocarbonyl)-5-nitropyridin-2-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-yl]carbamate 
• 882856-83-9 tert-butyl [(3R,4R)-1-[5-amino-6-(aminocarbonyl)pyridin-2-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-yl]carbamate 
• 882856-84-0 tert-butyl [(3R,4R)-1-(2-methyl-4-oxo-3,4-dihydropyrido[3,2-d]pyrimidine-6-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-yl]carbamate 
• 267243-48-1 6-amino-7-bromopyrido[3,2-d]pyrimidin-4(3H)-one 
• 267243-49-2 7-bromo-6-fluoropyrido[3,2-d]pyrimidin-4(3H)-one 
• 267243-47-0 5-bromo-3,6-diaminopyridine-2-carboxamide 
• 267243-46-9 6-amino-5-bromo-3-nitropyridine-2-carboxamide 
• 267243-50-5 7-bromo-4-[N-(3-chloro-4-fluorophenyl)amino]-6-fluoropyrido[3,2-d]pyrimidine 
• 267243-52-7 4-[N-(3-chloro-4-fluorophenyl)amino]-6-fluoro-7-[(1E)-4-(4-morpholinyl)-1-butenyl]pyrido[3,2-d]pyrimidine 
• 267243-54-9 4-[N-(3-chloro-4-fluorophenyl)amino]-6-fluoro-7-[4-(4-morpholinyl)butyl]pyrido[3,2-d]pyrimidine 
• 267243-53-8 6-amino-4-[N-(3-chloro-4-fluorophenyl)amino]-7-[(1E)-4-(4-morpholinyl)-1-butenyl]pyrido[3,2-d]pyrimidine 
• 267243-55-0 6-amino-4-[N-(3-chloro-4-fluorophenyl)amino]-7-[4-(4-morpholinyl)butyl]pyrido[3,2-d]pyrimidine 

Relevant articles and documents

NITROGEN HETEROCYCLIC COMPOUNDS AND METHODS OF USE

The present disclosure relates to compounds of formula (I): and pharmaceutically acceptable salts and stereoisomers thereof. The present disclosure also relates to methods of preparing the compounds, compositions comprising the compounds, and methods of using the compounds as inhibitors of receptor tyrosine kinases, in particular oncogenic mutants of ErbB-receptors e.g. in the treatment of cancer.

QUINOLINES AND RELATED ANALOGS AS SIRTUIN MODULATORS

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

HETEROCYCLIC CARBOXYLIC ACID AMIDES AS PDK1 INIHIBITORS

The present invention encompasses compounds of general formula (1) wherein the groups R1 to R4, Qa, Qb, QH, L and n are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, pharmaceutical preparations which contain such compounds and their use as medicaments.