171178-50-0Relevant articles and documents
Synthetic method of 2,6-dihalopyridine-3-carboxylic acid
-
Paragraph 0020, (2019/04/06)
The invention discloses a synthetic method of 2,6-dihalopyridine-3-carboxylic acid and belongs to the field of medicine intermediate synthesis. The synthetic method comprises the following steps: dissolving 2,6-dihalopyridine and Boc2O in an organic solvent; dropwise adding LDA or i-Pr2NMgCl-LiCl to react at a low temperature; then adding an acid-water solution to raise the temperature to react; and adding alkali to adjust pH to obtain 2,6-dihalopyridine-3-carboxylic acid. In addition, by adding LDA into 2,6-dihalopyridine at an ultralow temperature to abstract protons, and then adding DBU-CO2to react and quenching the solution, the 2,6-dihalopyridine-3-carboxylic acid is obtained. The two methods solve the problem that the yield is low by adopting a conventional CO2 introducing method for scaled production and the inter-batch operating repeatability is good.
COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS
-
Page/Page column 273; 278-279, (2010/11/19)
Disclosed is a composition for agricultural use, which is used for controlling or preventing plant diseases caused by plant pathogens. The composition for agricultural use contains a compound represented by formula (1), a salt thereof or a hydrate of the compound or the salt. (1) [In the formula, Z represents an oxygen atom, a sulfur atom or NRz; and E represents a furyl group, a thienyl group, a pyrrolyl group, a tetrazolyl group, a thiazolyl group, a pyrazolyl group, a phenyl group or the like.]
HETEROCYCLIC TYPE CINNAMIDE DERIVATIVE
-
Page/Page column 111, (2009/02/10)
Disclosed is a compound represented by the formula (I) below or a pharmacologically acceptable salt thereof. Also disclosed is a use of the compound or salt as a pharmaceutical product. (In the formula, Ar1 represents a triazolyl group or the l