171336-76-8 Usage
General Description
"2,4-Pyrrolidinedicarboxylic acid, 4-amino-1-(phenylmethyl)-, (2R,4R)-" is a chemical compound that belongs to the category of pyrrolidine carboxylic acids. It is also known as L-trans-4-hydroxyproline, which is a non-proteinogenic amino acid commonly found in collagen. 2,4-Pyrrolidinedicarboxylic acid, 4-amino-1-(phenylmethyl)-, (2R,4R)- has two stereoisomers, denoted as (2R,4R) and (2S,4S). The (2R,4R) isomer is the biologically active form and is involved in the biosynthesis of collagen and other proteins in the body. It plays a crucial role in maintaining the structure and strength of connective tissues, making it an important component in the field of medicine and cosmetics. Additionally, it has potential applications in the pharmaceutical industry for the development of drugs targeting collagen-related diseases and disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 171336-76-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,1,3,3 and 6 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 171336-76:
(8*1)+(7*7)+(6*1)+(5*3)+(4*3)+(3*6)+(2*7)+(1*6)=128
128 % 10 = 8
So 171336-76-8 is a valid CAS Registry Number.
171336-76-8Relevant articles and documents
Synthesis and metabotropic glutamate receptor antagonist activity of N1-substituted analogs of 2R,4R-4-aminopyrrolidine-2,4-dicarboxylic acid
Valli, Matthew J.,Schoepp, Darryle D.,Wright, Rebecca A.,Johnson, Bryan G.,Kingston, Ann E.,Tomlinson, Rosemarie,Monn, James A.
, p. 1985 - 1990 (2007/10/03)
A series of N1-substituted derivatives of (2R,4R)-4-aminopyrrolidine- 2,4-dicarboxylate (2R,4R-APDC) has been prepared as constrained analogs of γ-substituted glutamic acids and examined for their effects at recombinant metabotropic glutamate receptor (mGluR) subtypes in vitro. Appropriate substitution of the N1 position of 2R,4R-APDC resulted in the identification of a number of selective group II mGluR antagonists.
Pyrrolidinyl di-carboxylic acid derivatives as metabotropic glutamate receptor antagonists
-
, (2008/06/13)
The present invention provides pyrrolidinyl di-carboxylic acid derivatives that affect certain excitatory amino acid receptors, and are useful in the treatment of neurological disorders and psychiatric disorders. This invention further provides novel pyrr
