171774-99-5Relevant articles and documents
TBD- or PS-TBD-catalyzed one-pot synthesis of cyanohydrin carbonates and cyanohydrin acetates from carbonyl compounds
Matsukawa, Satoru,Kimura, Junya,Yoshioka, Miki
supporting information, (2016/08/30)
Cyanation reactions of carbonyl compounds with methyl cyanoformate or acetyl cyanide catalyzed by 5 mol % of 1,5,7-triazabicyclo[4,4,0]dec-5-ene (TBD) were examined. Using methyl cyanoformate, the corresponding cyanohydrin carbonates were readily obtained in high yield for aromatic and aliphatic aldehydes and ketones. Similar results were obtained when acetyl cyanide was used as the cyanide source. The polymer-supported catalyst, PS-TBD, also acted as a good catalyst for this reaction. PS-TBD was easily recovered and reused with minimal activity loss.
Improved three-component lewis acid-free approach for the synthesis of protected racemic cyanohydrins
Kumaraswamy,Ankamma
experimental part, p. 447 - 455 (2009/04/11)
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Processes for producing alpha -cyanohydrin esters and alpha -hydroxy acids
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, (2008/06/13)
In the presence of a metal catalyst such as a samarium compound, an enol ester compound shown by the formula (1) is reacted with a carbonyl compound shown by the formula (3) and a cyanogenation agent to produce an alpha -cyanohydrin ester shown by the formula (4): wherein R1, R7, and R8 are the same or different from each other, each representing a non-reactive atom or a non-reactive organic group; R2, R3, and R4 are the same or different from each other, each representing a hydrogen atom or an alkyl group having 1 to 5 carbon atoms. By hydrolyzing the obtained compound, the corresponding alpha -hydroxy acid or a salt thereof can be obtained. According to the above processes, an alpha -cyanohydrin ester and an alpha -hydroxy acid can be obtained in high yields.