171820-73-8 Usage
General Description
Boc-Dab(Aloc)-OH is a chemical compound that is used in the field of organic chemistry. The "Boc" in the name refers to the tert-butyloxycarbonyl protecting group, which is commonly used to protect amines during chemical reactions. "Dab" stands for 2,2-diaminobutyric acid, which is an amino acid derivative that can be used in peptide synthesis. "Aloc" refers to the allyloxycarbonyl protecting group, which is also used to protect amines. Finally, "OH" indicates that the compound has a hydroxyl group, or an alcohol functionality. Overall, Boc-Dab(Aloc)-OH is a versatile compound that can be used to protect and modify amino acids and peptides in organic synthesis.
Check Digit Verification of cas no
The CAS Registry Mumber 171820-73-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,1,8,2 and 0 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 171820-73:
(8*1)+(7*7)+(6*1)+(5*8)+(4*2)+(3*0)+(2*7)+(1*3)=128
128 % 10 = 8
So 171820-73-8 is a valid CAS Registry Number.
171820-73-8Relevant articles and documents
An Allyl Protection and Improved Purification Strategy Enables the Synthesis of Functionalized Phosphonamidate Peptides
Cramer, Jonathan,Klebe, Gerhard
supporting information, p. 1857 - 1866 (2017/04/06)
For modern biophysical methods such as isothermal titration calorimetry, high purity of the inhibitor of interest is indispensable. Herein, we describe a procedure for the synthesis and purification of functionalized phosphonamidate peptides that is able to generate inhibitors for the metalloprotease thermolysin for use in biophysical experiments. The method utilizes an allyl ester/alloc protection strategy and takes advantage of a fast and effective solid-phase extraction (SPE) purification step. Applying this strategy, we were able to synthesize a series of highly polar inhibitors featuring amino- and hydroxy-functionalized side chains in excellent purity.
