17207-57-7Relevant articles and documents
Kinetic resolution of oxazinones: Rational exploration of chemical space through the design of experiments
Renzi, Polyssena,Kronig, Christel,Carlone, Armando,Er?ksüz, Serap,Berkessel, Albrecht,Bella, Marco
, p. 11768 - 11775 (2014/10/15)
The organocatalytic kinetic resolution of 4-substituted oxazinones has been optimised (selectivity factor S up to 98, chiral oxazinone ee values up to 99.6% (1a-g) and product ee values up to 90% (3a-g)) in a rational way by applying the Design of Experiments (DoE) approach.
Synthesis, in vitro and in vivo biological evaluation, and comprehensive understanding of structure-activity relationships of dipeptidyl boronic acid proteasome inhibitors constructed from β-amino acids
Zhu, Yongqiang,Wu, Gang,Zhu, Xinrong,Ma, Yuheng,Zhao, Xin,Li, Yuejie,Yuan, Yunxia,Yang, Jie,Yu, Sen,Shao, Feng,Lei, Meng
supporting information; experimental part, p. 8619 - 8626 (2011/03/20)
An extensive structure-activity relationship (SAR) study of 72 dipeptidyl boronic acid proteasome inhibitors constructed fromβ -amino acids is reported. SAR analysis revealed that bicyclic groups at the R1 position, 3-F substituents at the Rsu
A facile and stereocontrolled synthesis of syn-α-alkyl α-hydroxy β-amino acids
Nocioni, Alessandra Maria,Papa, Carmela,Tomasini, Claudia
, p. 8453 - 8456 (2007/10/03)
The diastereoselective synthesis of syn-α-alkyl α-hydroxy β-amino acids 4a-h was easily accomplished by reaction of the sodium dianion of the corresponding anti α-alkyl β-benzoylamino acid methyl esters with iodine. The intermediate α-iodo derivatives spontaneously afforded cis-oxazolines which, upon hydrolysis, provided the desired products, with diastereoselectivities up to 99:1.
