172649-57-9

Basic information

• Product Name: 5-chloromethyloxazole
• Synonyms: OXAZOLE, 5-(CHLOROMETHYL)-;5-chloromethyloxazole;5-(CchloroMethyl)oxazole
• CAS NO: 172649-57-9
• Molecular Formula: C4H4ClNO
• Molecular Weight: 117.53
• Mol File: 172649-57-9.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 5-chloromethyloxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloromethyloxazole(172649-57-9)
• EPA Substance Registry System: 5-chloromethyloxazole(172649-57-9)

Safety Data

• Hazardous Substances Data: 172649-57-9(Hazardous Substances Data)

Usage

General Description

5-chloromethyloxazole is a chemical compound with the molecular formula C4H4ClNO. It belongs to the oxazole class of organic compounds and contains a chloride group and a methyl group attached to the oxazole ring. The chemical structure of 5-chloromethyloxazole makes it a versatile building block for the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds. It is also used as a reagent in organic synthesis and as a precursor for the preparation of oxazole-based compounds with potential biological activities. Additionally, 5-chloromethyloxazole has been investigated for its potential as an antibacterial and antifungal agent, although further research is needed to elucidate its full range of biological properties and applications.

Upstream product

• 127232-41-1 1,3-oxazol-5-ylmethanol 

Downstream Products

• 947771-07-5 2-(oxazol-5-yl)acetonitrile 

Relevant articles and documents

Synthesis of Arylethylamines via C(sp3)-C(sp3) Palladium-Catalyzed Cross-Coupling

Substituted arylethylamines represent a key structural motif in natural, pharmaceutical, and agrochemical compounds. Access to such scaffolds has been the subject of long-standing synthetic interest. Herein, we report the synthesis of such scaffolds via a palladium-catalyzed C(sp3)-C(sp3) coupling between (chloromethyl)aryls and air-/moisture-stable N,N-dialkylaminomethyltrifluoroborate salts. Rapid hit identification was achieved using microscale high-throughput experimentation and was followed by millimolar-scale reaction parameter optimization. A range of structurally and electronically varied arylethylamine products were obtained in moderate to excellent yields (27-96%, >60 examples). The reaction mechanism is proposed to proceed via formation of a trialkylbenzylammonium species prior to oxidative addition.

ANTIPROLIFERATIVE BENZO [B] AZEPIN- 2 - ONES

Disclosed are compounds of Formula (I) or pharmaceutically acceptable salts thereof, wherein W, X, Y, Z, R1, R2, R3 and R4 are described in this application, and methods of using said compounds in the treatment of cancer.

RETROVIRAL PROTEASE INHIBITING PIPERAZINE COMPOUNDS

Retroviral protease inhibiting compounds of the formula: STR1 are disclosed.