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172846-56-9

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172846-56-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 172846-56-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,2,8,4 and 6 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 172846-56:
(8*1)+(7*7)+(6*2)+(5*8)+(4*4)+(3*6)+(2*5)+(1*6)=159
159 % 10 = 9
So 172846-56-9 is a valid CAS Registry Number.

172846-56-9Relevant articles and documents

Modular Solid-Phase Synthesis of Antiprotozoal Barnesin Derivatives

Roman, Dávid,Ragu?, Luka,Keiff, Fran?ois,Meyer, Florian,Barthels, Fabian,Schirmeister, Tanja,Kloss, Florian,Beemelmanns, Christine

, p. 3744 - 3748 (2020)

Here, we applied and optimized a solid support (SP)-based Horner-Wadsworth-Emmons reagent to prepare SP-bound vinylogous amino acids. Subsequent SP-based peptide synthesis, global deprotection, and chemical modifications yielded 14 lipodipeptides carrying

Backbone thioamide directed macrocyclisation: Lactam stapling of peptides

Hutton, Craig A.,Taresh, Ameer B.

supporting information, p. 1488 - 1492 (2022/03/01)

A novel method for lactam stapling of Asp/Lys-containing peptides has been developed that does not require coupling agents. A backbone thioamide is incorporated at the N-terminal side of the aspartate residue. Ag(i)-promoted activation of the thioamide in the vicinity of the Asp carboxylate generates a cyclic isoimide intermediate that is trapped by the Lys amine to generate the macrolactam. This method is suitable for generation of i,i+2, i,i+3, and i,i+4-spaced lactam-bridged peptides. This journal is

NEW TARGETED CYTOTOXIC RATJADONE DERIVATIVES AND CONJUGATES THEREOF

-

Paragraph 00206; 00207, (2019/02/25)

The present invention is directed to novel natural product-derived ratjadone-based compounds useful as payloads (or toxins) in drug-conjugates constructs with cell target binding moieties (CTBM) and payload-linker compounds useful in connection with drug conjugates. The present invention further relates to new ratjadone compositions including the aforementioned payloads, payload-linkers and drug conjugates, and methods for using these payloads, payload-linkers and drug conjugates, to treat pathological conditions including cancer, inflammatory and infectious diseases.

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