17302-46-4

Basic information

• Product Name: METHYL 5-NITROSALICYLATE
• Synonyms: RARECHEM AL BF 0192;5-Nitrosalicyclic Acid Methyl Ester;5-NITROSALICYLIC ACID METHYL ESTER;2-Hydroxy-5-nitrobenzoic acid methyl ester;Einecs 241-330-7;5-nitrosalicylate;METHYL 5-NITROSALICYLATE;METHYL 2-HYDROXY-5-NITROBENZOATE
• CAS NO: 17302-46-4
• Molecular Formula: C₈H₇NO₅
• Molecular Weight: 197.14
• EINECS: 241-330-7
• Product Categories: Aromatic Esters;alcohol|nitro-compound|carboxylic ester
• Mol File: 17302-46-4.mol
• Article Data: 45

Chemical Properties

• Melting Point: 114-117°C
• Boiling Point: 328.7 °C at 760 mmHg
• Flash Point: 152.6 °C
• Appearance: /
• Density: 1.432 g/cm³
• Vapor Pressure: 9.76E-05mmHg at 25°C
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform, DCM, Methanol
• PKA: 6.82±0.22(Predicted)
• Water Solubility: Insoluble in water.
• CAS DataBase Reference: METHYL 5-NITROSALICYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 5-NITROSALICYLATE(17302-46-4)
• EPA Substance Registry System: METHYL 5-NITROSALICYLATE(17302-46-4)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 17302-46-4(Hazardous Substances Data)

Usage

Description

METHYL 5-NITROSALICYLATE, also known as 5-Nitrosalicylic Acid Methyl Ester, is a salicylic acid derivative characterized by its anti-inflammatory properties. It is a compound that has been found to exhibit significant effects in reducing inflammation, particularly in the context of colitis.

Uses

Used in Pharmaceutical Industry:
METHYL 5-NITROSALICYLATE is used as an anti-inflammatory agent for its ability to alleviate symptoms associated with colitis. The compound works by targeting the underlying inflammation in the colon, providing relief and potentially aiding in the treatment of the condition.

InChI:InChI=1/C8H7NO5/c1-14-8(11)6-4-5(9(12)13)2-3-7(6)10/h2-4,10H,1H3/p-1

Upstream product

• 119-36-8 methyl salicylate 
• 67-56-1 methanol 
• 1641-03-8 4-hydroxy-6-nitro-2H-chromene-2-one 
• 93360-60-2 4-chloro-3,6-dinitrocoumarin 
• 618-95-1 methyl 3-nitrobenzoate 
• 96-97-9 5-nitrosalicylic acid 
• 105-45-3 acetoacetic acid methyl ester 
• 666857-90-5 cis-methyl 3-(pyrrolidin-1-yl)but-2-enoate 
• 69-72-7 salicylic acid 
• 1028591-91-4 methyl 2-(methoxycarbonyl)-4-nitrophenyl phosphate 
• 124-41-4 sodium methylate 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 13736-92-0 2-butanoyloxy-5-nitrobenzoic acid 
• 946-32-7 2-hydroxy-5-nitrobenzhydrazide 
• 57148-23-9 2-ethoxy-5-nitro-benzoic acid 
• 16000-01-4 N,N'-<1,5-Naphthylen>-bis-benzimidsaeure-bis<4-nitro-2-methoxycarbonyl-phenylester> 
• 136437-23-5 5',5''-dinitro-N,N'-disalicyloyl-1,2-ethanediamine 
• 130839-94-0 C₃₃H₃₀N₆O₁₈ 
• 39224-61-8 2-hydroxy-5-nitrobenzyl alcohol 
• 114259-78-8 1-(2-Hydroxy-5-nitrobenzoyl)pyrrolidine 
• 61294-22-2 methyl 2-acetoxy-5-nitrobenzoate 
• 135790-63-5 methyl 2-(2',3',4',6'-tetra-O-acetyl-β-D-glucopyranosyloxy)-5-nitrobenzoate 
• 267897-49-4 2-octyloxy-5-nitro-benzoic acid methyl ester 
• 807631-38-5 2-(11-benzyloxyundecyloxy)-5-nitrobenzoic acid methyl ester 
• 632626-83-6 2-difluoromethoxy-5-nitro-benzoic acid methyl ester 
• 34841-11-7 methyl 2-methoxy-5-nitrobenzoate 

Relevant articles and documents

Stereoisomers and functional groups in oxidorhenium(v) complexes: Effects on catalytic activity

The syntheses of oxidorhenium(v) complexes [ReOCl(L1a-c)2] (3a-c), equipped with the bidentate, mono-anionic phenol-dimethyloxazoline ligands HL1a-c are described. Ligands HL1b-c contain functional groups on the phenol ring, compared to parent ligand 2-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)-phenol H1a; namely a methoxy group ortho to the hydroxyl position (2-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)-6-methoxyphenol, H1b), or a nitro group para to the hydroxyl position (2-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)-4-nitrophenol, H1c). Furthermore, oxidorhenate(v) complexes (NBu4)[ReOCl3(L1a-b)] (2a-b) were synthesized for solid state structural comparisons to 3a-b. All novel complexes are fully characterized including NMR, IR and UV-Vis spectroscopy, MS spectrometry, X-ray crystallography, elemental analysis as well as cyclic voltammetry. The influence of functional groups (R = -H, -OMe and -NO2) on the catalytic activity of 3a-c was investigated in two benchmark catalytic reactions, namely cyclooctene epoxidation and perchlorate reduction. In addition, the previously described oxidorhenium(v) complex [ReOCl(oz)2] (4), employing the phenol-oxazoline ligand 2-(4,5-dihydro-2-oxazolyl)phenol Hoz, was included in these catalysis studies. Complex 4 is a rare case in oxidorhenium(v) chemistry where two stereoisomers could be separated and fully characterized. With respect to the position of the oxazoline nitrogen atoms on the rhenium atom, these two stereoisomers are referred to as N,N-cis and N,N-trans isomer. A potential correlation between spectroscopic and structural data to catalytic activity was evaluated.

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Reliable folding of hybrid tetrapeptides into short β-hairpins

Five hybrid tetrapeptides, each consisting a central dipeptide segment of α-amino acid residues flanked by two aromatic γ-amino acid residues, are found to fold into well-defined β-hairpin conformations as shown by NMR, computational study, and X-ray structures. The turn loop of this β-hairpin motif accommodates different two-residue α-amino acid sequences from the highly flexible Gly-Gly, to the more restricted D-Pro-Gly. The presence of α-amino acid side chains enhances the stabilities of the β-hairpins with the exception of D-Pro-Gly-which results in destabilization. Based on this hairpin/turn motif, a variety of different dipeptide sequences of α-amino acids which rarely occur in β-turns can be introduced and presented as two-residue loops.

BICYCLIC-FUSED HETEROARYL OR ARYL COMPOUNDS

Compounds, tautomers and pharmaceutically acceptable salts of the compounds of Formula (Ia) are disclosed which are inhibitors of lnterleukin-1 receptor associated kinase (IRAK4). Methods of treatment, methods of synthesis, and intermediates are also disclosed as defined in the specification.