17332-57-9

Basic information

• Product Name: 2,4'-IMINO-DIBENZOIC ACID
• Synonyms: 2,4'-IMINO-DIBENZOIC ACID;N-(4-CARBOXYPHENYL)ANTHRANILIC ACID;2-((4-Carboxyphenyl)aMino)benzoic acid
• CAS NO: 17332-57-9
• Molecular Formula: C₁₄H₁₁NO₄
• Molecular Weight: 257.24144
• Product Categories: pharmacetical
• Mol File: 17332-57-9.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 490.2 °C at 760 mmHg
• Flash Point: 250.3 °C
• Appearance: /
• Density: 1.424 g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2,4'-IMINO-DIBENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4'-IMINO-DIBENZOIC ACID(17332-57-9)
• EPA Substance Registry System: 2,4'-IMINO-DIBENZOIC ACID(17332-57-9)

Safety Data

• Hazardous Substances Data: 17332-57-9(Hazardous Substances Data)

Usage

General Description

2,4'-IMINO-DIBENZOIC ACID, also known as 2,4'-Diaminobenzoic acid, is a chemical compound with the molecular formula C13H11NO4. It is a derivative of benzoic acid and contains two amino groups at the 2 and 4' positions of the benzene ring. 2,4'-IMINO-DIBENZOIC ACID has a variety of uses, including as a building block in the synthesis of pharmaceuticals and dyes. It is also used in the production of polymers and as an intermediate in organic synthesis. 2,4'-IMINO-DIBENZOIC ACID is considered to be a potentially hazardous compound and should be handled with care.

Upstream product

• 16463-38-0 potassium 2-chlorobenzoate 
• 150-13-0 4-amino-benzoic acid 
• 118-91-2 ortho-chlorobenzoic acid 
• 71-41-0 pentan-1-ol 
• 88-65-3 2-bromobenzoic-acid 
• 88-67-5 2-Iodobenzoic acid 
• 619-42-1 4-methoxycarbonylphenyl bromide 
• 134-20-3 2-carbomethoxyaniline 
• 17763-70-1 methyl 2-(trifluoromethylsulfonyloxy)benzoate 
• 619-45-4 4-methoxycarbonyl aniline 

Downstream Products

• 42946-36-1 9-oxo-9,10-dihydro-acridine-2-carboxylic acid 
• 64046-80-6 5-Aminoacridin-3-carbonsaeure 
• 875272-03-0 9-phenoxyacridine-2-carboxylic acid diethylamide 
• 877629-53-3 (4-methyl-piperazin-1-yl)-(9-phenoxy-acridin-2-yl)-methanone 
• 1415651-26-1 4-acetamidophenyl-2-[{4-{(4-acetamidophenoxy)carbonyl}phenyl}{2-(nitrooxy)ethyl}amino] benzoate 

Relevant articles and documents

Synthesis, cytotoxicity evaluation, and molecular modeling studies of 2,N10-substituted acridones as DNA-intercalating agents

Acridine-based compounds possess anticancer activities by intercalating to DNA. Although they have chemotherapeutic potential, acridine-based compounds are not used to treat cancer. In this study, 2,N10-acridone derivatives are designed and synthesized based on acridone, a ketone derivative of acridine. Herein, acridone is functionalized with alkyl side chains containing terminal nitrogen-based moieties at the N10-position and substituted at the C2-position. The products are evaluated for in vitro cytotoxicity against four cancer cell lines: Molt-3, HepG2, A549, and HuCCA-1. The derivative bearing two butyl piperidine side chains at the C2- and N10-positions is the most active, with IC50 values ranging from 2.96 to 9.46 μM. Molecular modeling studies supported the binding of the derivatives to DNA by intercalation, thereby confirming the observed cytotoxic effects.

Bis-substituted diphenylamine arylidene hydrazones for the synthesis of new binuclear organotin(IV) complexes: Crystal structure, DNA cleavage and molecular docking

Five dinuclear organotin(IV) complexes, R4Sn2La (R = Me, Ph) and R4Sn2Lb (R = Me, Ph and Bu) have been synthesized from reaction of R2SnCl2 with 2,4′- and 2,2′-bis-sub

Synthesis and investigation of anti-inflammatory activity of novel nitric oxide donating hybrid drugs

A small library of nitric oxide donating groups, 4-acetamidophenyl-2-[{2- (nitrooxy)ethyl}(phenyl) amino]benzoate (5a-e) possessing a variety of substituents (-H, -NO2, -CH3, -acetamidophenyl, -SO 2NH2) attached to the fourth position of phenyl ring were synthesized and evaluated for anti-inflammatory, analgesic and ulcerogenic potential. Structure-activity relationship data showed that the 2-phenylaminobenzoic acid skeleton is required for selective COX-2 inhibition. Among all compounds 4-acetamidophenyl-2-[{2-(nitrooxy)ethyl}(phenyl)amino] benzoate (5a) has shown potent anti-inflammatory activity while 4-acetamidophenyl-2-[{4-{(4-acetamidophenoxy)carbonyl} phenyl}{2-(nitrooxy) ethyl}amino]benzoate (5d) has shown potent analgesic activity compared to standard drug diclofenac.